A Single-Center, Retrospective Cohort Study Evaluating the Use of Probiotics for the Prevention of Hospital-Onset
antibiotic stewardship
antibiotics
clostridium difficile infection
probiotics
Journal
Hospital pharmacy
ISSN: 0018-5787
Titre abrégé: Hosp Pharm
Pays: United States
ID NLM: 0043175
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
pmc-release:
01
02
2024
entrez:
16
1
2023
pubmed:
17
1
2023
medline:
17
1
2023
Statut:
ppublish
Résumé
Exposure to antimicrobials is a known risk factor for To evaluate the rates of hospital-onset Clostridioides difficile infection (HO-CDI) among patients who received intravenous (IV) antibiotics plus probiotics versus IV antibiotics alone. Retrospective, single-center cohort study. We included adult patients that received at least 1 dose of IV antibiotics and had a hospital length of stay of at least 3 days between August 2017 and July 2020. Patients were separated into 2 cohorts, either receipt of probiotics or non-receipt of probiotics. Patients with positive We identified 17 598 patients that received IV antibiotics alone and 2659 patients received IV antibiotics plus probiotics. HO-CDI occurred in 46 (0.26%) of those that received antibiotics alone compared to 5 (0.19%) of those that received probiotics with IV antibiotics (OR 0.72, 95% CI 0.28-1.81). ICU admission (OR 1.81, 95% CI 1.02-3.19) and history of CDI (OR 3.37, 95% CI 1.07-10.97) in the past 12 months were associated with a higher incidence of HO-CDI. The addition of probiotics did not reduce the incidence of HO-CDI among inpatients receiving IV antibiotics.
Sections du résumé
Background
UNASSIGNED
Exposure to antimicrobials is a known risk factor for
Objective
UNASSIGNED
To evaluate the rates of hospital-onset Clostridioides difficile infection (HO-CDI) among patients who received intravenous (IV) antibiotics plus probiotics versus IV antibiotics alone.
Design
UNASSIGNED
Retrospective, single-center cohort study.
Methods
UNASSIGNED
We included adult patients that received at least 1 dose of IV antibiotics and had a hospital length of stay of at least 3 days between August 2017 and July 2020. Patients were separated into 2 cohorts, either receipt of probiotics or non-receipt of probiotics. Patients with positive
Results
UNASSIGNED
We identified 17 598 patients that received IV antibiotics alone and 2659 patients received IV antibiotics plus probiotics. HO-CDI occurred in 46 (0.26%) of those that received antibiotics alone compared to 5 (0.19%) of those that received probiotics with IV antibiotics (OR 0.72, 95% CI 0.28-1.81). ICU admission (OR 1.81, 95% CI 1.02-3.19) and history of CDI (OR 3.37, 95% CI 1.07-10.97) in the past 12 months were associated with a higher incidence of HO-CDI.
Conclusion
UNASSIGNED
The addition of probiotics did not reduce the incidence of HO-CDI among inpatients receiving IV antibiotics.
Identifiants
pubmed: 36644740
doi: 10.1177/00185787221120153
pii: 10.1177_00185787221120153
pmc: PMC9837316
doi:
Types de publication
Journal Article
Langues
eng
Pagination
57-61Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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