Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent.
Fcer1a
Microtus agrestis
genetics
genomics
immunology
inflammation
inflammatory response
phenotypic expression
sex
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
16 01 2023
16 01 2023
Historique:
received:
07
02
2022
accepted:
22
12
2022
entrez:
16
1
2023
pubmed:
17
1
2023
medline:
19
1
2023
Statut:
epublish
Résumé
The genotype of an individual is an important predictor of their immune function, and subsequently, their ability to control or avoid infection and ultimately contribute offspring to the next generation. However, the same genotype, subjected to different intrinsic and/or extrinsic environments, can also result in different phenotypic outcomes, which can be missed in controlled laboratory studies. Natural wildlife populations, which capture both genotypic and environmental variability, provide an opportunity to more fully understand the phenotypic expression of genetic variation. We identified a synonymous polymorphism in the high-affinity Immunoglobulin E (IgE) receptor (GC and non-GC haplotypes) that has sex-dependent effects on immune gene expression, susceptibility to infection, and reproductive success of individuals in a natural population of field voles (
Identifiants
pubmed: 36645701
doi: 10.7554/eLife.77666
pii: 77666
pmc: PMC9842384
doi:
pii:
Substances chimiques
Receptors, IgE
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023, Wanelik et al.
Déclaration de conflit d'intérêts
KW, MB, JB, IF, JJ, CT, SP No competing interests declared
Références
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Conserv Physiol. 2015 Dec 21;3(1):cov058
pubmed: 27293740
PLoS One. 2011;6(7):e22221
pubmed: 21765955
Nat Genet. 1997 Sep;17(1):11-2
pubmed: 9288086
J Allergy Clin Immunol. 1991 Sep;88(3 Pt 1):365-75
pubmed: 1890265
Science. 1999 Mar 12;283(5408):1748-52
pubmed: 10073943
Epidemics. 2009 Mar;1(1):35-46
pubmed: 21352750
Mol Ecol Resour. 2017 Sep;17(5):1009-1024
pubmed: 28271620
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Front Microbiol. 2018 Jan 31;9:85
pubmed: 29445365
J Allergy Clin Immunol. 2012 Mar;129(3):840-845.e21
pubmed: 22075330
Oxid Med Cell Longev. 2016;2016:5698931
pubmed: 26881031
Free Radic Biol Med. 2010 Dec 1;49(11):1603-16
pubmed: 20840865
Nat Genet. 2006 Feb;38(2):218-22
pubmed: 16429159
J Transl Med. 2013 May 06;11:112
pubmed: 23642304
Int J Cancer. 1989 Dec 15;44(6):1028-33
pubmed: 2558077
Int J Parasitol. 2018 May;48(6):463-471
pubmed: 29476867
Front Genet. 2016 Oct 13;7:183
pubmed: 27790248
Science. 2010 Oct 8;330(6001):243-6
pubmed: 20929776
Curr Opin Immunol. 2014 Dec;31:31-7
pubmed: 25278425
Allergy. 2008 Nov;63(11):1418-27
pubmed: 18925878
Int J Immunogenet. 2010 Apr;37(2):139-41
pubmed: 20141544
Nat Rev Genet. 2011 Jan;12(1):56-68
pubmed: 21164525
Parasitology. 2014 Jul;141(8):997-1017
pubmed: 24612619
Allergy. 2006 Oct;61(10):1230-3
pubmed: 16942574
Clin Exp Allergy. 2008 Aug;38(8):1254-63
pubmed: 18727793
Allergy. 2004 Apr;59(4):428-35
pubmed: 15005767
Nature. 1991 Aug 15;352(6336):595-600
pubmed: 1865923
Nat Rev Genet. 2008 Dec;9(12):911-22
pubmed: 19002143
Sci Rep. 2020 May 4;10(1):7444
pubmed: 32366957
Nat Rev Immunol. 2010 Feb;10(2):103-10
pubmed: 20081870
Mol Ecol. 2018 Feb;27(4):1044-1052
pubmed: 29290094
Proc Biol Sci. 2011 Apr 7;278(1708):1098-106
pubmed: 20926440
Annu Rev Immunol. 2006;24:147-74
pubmed: 16551246
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Parasite Immunol. 2013 Nov;35(11):386-95
pubmed: 23550923
J Immunol. 2003 Aug 15;171(4):1927-33
pubmed: 12902495
Nature. 2004 Sep 23;431(7007):446-9
pubmed: 15386011
PLoS Genet. 2011 Oct;7(10):e1002343
pubmed: 22039363
Bioessays. 1999 Mar;21(3):238-46
pubmed: 10333733
J Immunol. 2003 Mar 15;170(6):2993-3001
pubmed: 12626552
Clin Exp Dermatol. 2013 Jun;38(4):410-6
pubmed: 23621092
Comp Biochem Physiol B Biochem Mol Biol. 2010 Apr;155(4):427-34
pubmed: 20109576
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3714-9
pubmed: 9520432
J Clin Invest. 2002 Feb;109(3):295-9
pubmed: 11827987
Trends Ecol Evol. 1996 Aug;11(8):317-21
pubmed: 21237861
Nature. 1994 Jan 13;367(6459):183-6
pubmed: 8114916
Allergy. 2006 May;61(5):589-97
pubmed: 16629789
Science. 2010 Oct 29;330(6004):662-5
pubmed: 21030656
Nature. 2009 Sep 10;461(7261):218-23
pubmed: 19741703
PLoS Biol. 2014 Jul 08;12(7):e1001901
pubmed: 25004450
J Endocr Soc. 2018 Oct 22;3(1):91-107
pubmed: 30582096
Oecologia. 2010 Mar;162(3):653-61
pubmed: 19916066
PLoS Genet. 2008 Aug;4(8):e1000166
pubmed: 18846228
Front Immunol. 2014 Feb 19;5:58
pubmed: 24600449
Hum Immunol. 2012 Mar;73(3):301-5
pubmed: 22222815
Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8119-24
pubmed: 24843175
Mol Ecol. 2011 Mar;20(5):893-909
pubmed: 21059128
Immunol Today. 1993 Jul;14(7):353-6
pubmed: 8363725
J R Soc Interface. 2015 Jan 6;12(102):20141004
pubmed: 25411407