Anti-Inflammatory Role of TRPV4 in Human Macrophages.
Journal
ImmunoHorizons
ISSN: 2573-7732
Titre abrégé: Immunohorizons
Pays: United States
ID NLM: 101708159
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
received:
16
12
2022
accepted:
16
12
2022
entrez:
16
1
2023
pubmed:
17
1
2023
medline:
19
1
2023
Statut:
ppublish
Résumé
The pathology of skin immune diseases such as atopic dermatitis is closely related to the overproduction of cytokines by macrophages. Although the pathological functions of macrophages in skin are known, mechanisms of how they detect the tissue environment remain unknown. TRPV4, a nonselective cation channel with high Ca2+ permeability, is activated at physiological temperatures from 27 to 35°C and involved in the functional control of macrophages. However, the relationship between TRPV4 function in macrophages and skin immune disease is unclear. In this study, we demonstrate that TRPV4 activation inhibits NF-κB signaling, resulting in the suppression of IL-1β production in both human primary monocytes and macrophages derived from human primary monocytes. A TRPV4 activator also inhibited the differentiation of human primary monocytes into GM-CSF M1 macrophages but not M-CSF M2 macrophages. We also observed a significant increase in the number of inducible NO synthase-positive/TRPV4-negative dermal macrophages in atopic dermatitis compared with healthy human skin specimens. Our findings provide insight into the physiological relevance of TRPV4 to the regulation of macrophages during homeostasis maintenance and raise the potential for TRPV4 to be an anti-inflammatory target.
Identifiants
pubmed: 36645854
pii: 237687
doi: 10.4049/immunohorizons.2200100
pmc: PMC10563396
doi:
Substances chimiques
TRPV Cation Channels
0
Cytokines
0
Anti-Inflammatory Agents
0
TRPV4 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-96Informations de copyright
Copyright © 2023 The Authors.
Références
Pflugers Arch. 2012 Apr;463(5):715-25
pubmed: 22374181
Biochem Biophys Res Commun. 2015 Mar 13;458(3):700-706
pubmed: 25686493
BMC Med Genomics. 2015 Oct 12;8:60
pubmed: 26459294
Cell Metab. 2017 Feb 7;25(2):412-427
pubmed: 28041958
J Clin Invest. 1997 Jun 15;99(12):3009-17
pubmed: 9185525
Nat Rev Immunol. 2008 Dec;8(12):958-69
pubmed: 19029990
Biochem J. 2018 Jun 21;475(12):1995-2008
pubmed: 29626160
J Biol Chem. 2010 Jun 11;285(24):18749-58
pubmed: 20413591
Sci Rep. 2017 Sep 5;7(1):10522
pubmed: 28874838
Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E270-82
pubmed: 25389363
Front Microbiol. 2021 Jan 11;11:567090
pubmed: 33505363
Sci Transl Med. 2012 Nov 7;4(159):159ra148
pubmed: 23136043
J Physiol Sci. 2014 Jan;64(1):47-57
pubmed: 24122170
Life Sci. 2008 Aug 29;83(9-10):339-45
pubmed: 18675280
Front Immunol. 2021 Mar 16;12:652846
pubmed: 33796114
J Eur Acad Dermatol Venereol. 2016 Feb;30(2):223-49
pubmed: 26449379
Front Immunol. 2014 Oct 07;5:491
pubmed: 25339958
J Immunol. 2010 Dec 1;185(11):6413-9
pubmed: 21084670
Nature. 2003 Jul 24;424(6947):434-8
pubmed: 12879072
Br J Dermatol. 2001 Aug;145(2):258-63
pubmed: 11531788
Nat Rev Immunol. 2014 May;14(5):289-301
pubmed: 24722477
J Neurosci. 2002 Aug 1;22(15):6408-14
pubmed: 12151520
J Biol Chem. 2020 Jul 17;295(29):9986-9997
pubmed: 32493776
Cells. 2020 Jan 15;9(1):
pubmed: 31952223
Nat Immunol. 2013 Oct;14(10):986-95
pubmed: 24048120
Cell Metab. 2008 Sep;8(3):257-65
pubmed: 18762026
J Immunol. 1995 Feb 15;154(4):1956-63
pubmed: 7836775
J Cell Sci. 2021 Jul 1;134(13):
pubmed: 34254641
Nat Immunol. 2014 Nov;15(11):1064-9
pubmed: 25240383
Osteoarthritis Cartilage. 2021 Jan;29(1):89-99
pubmed: 33395574
Immunity. 2015 Apr 21;42(4):756-66
pubmed: 25902485
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
J Immunol. 2016 Jan 1;196(1):428-36
pubmed: 26597012
Biochem Biophys Res Commun. 2022 Jan 22;589:35-40
pubmed: 34891039
Nature. 1997 Oct 23;389(6653):816-24
pubmed: 9349813
Front Immunol. 2017 May 04;8:503
pubmed: 28523001
Arch Immunol Ther Exp (Warsz). 2018 Feb;66(1):45-54
pubmed: 28623375
Biochim Biophys Acta. 2007 Aug;1772(8):937-46
pubmed: 17616360
Am J Respir Cell Mol Biol. 2014 Jun;50(6):1064-75
pubmed: 24392954
Immunity. 2013 Mar 21;38(3):570-80
pubmed: 23434060
J Neurosci. 2013 Apr 3;33(14):6154-9
pubmed: 23554496
Nat Rev Microbiol. 2011 Apr;9(4):244-53
pubmed: 21407241
PLoS One. 2011;6(10):e26591
pubmed: 22028915
Biochim Biophys Acta. 2007 Aug;1772(8):805-12
pubmed: 17368864
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9
pubmed: 20956320
Trends Immunol. 2004 Aug;25(8):402-5
pubmed: 15275637
Immunity. 1999 Oct;11(4):443-51
pubmed: 10549626
Am J Physiol Cell Physiol. 2010 Mar;298(3):C656-64
pubmed: 20032510
J Immunol. 2012 Jun 1;188(11):5752-65
pubmed: 22547697
Front Immunol. 2014 Oct 17;5:514
pubmed: 25368618
Int J Vasc Med. 2012;2012:605101
pubmed: 22848834