Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.
Journal
Lab animal
ISSN: 1548-4475
Titre abrégé: Lab Anim (NY)
Pays: United States
ID NLM: 0417737
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
28
09
2021
accepted:
14
11
2022
pubmed:
17
1
2023
medline:
7
2
2023
entrez:
16
1
2023
Statut:
ppublish
Résumé
Adolescent social neglect impairs social performance, but the underlying molecular mechanisms remain unclear. Here we report that isolation rearing of juvenile mice caused cooperation defects that were rescued by immediate social reintroduction. We also identified the transcription factor early growth response 2 (Egr2) in the medial prefrontal cortex (mPFC) as a major target of social isolation and resocialization. Isolation rearing increased corticosteroid production, which reduced the expression of Egr2 in the mPFC, including in oligodendrocytes. Overexpressing Egr2 ubiquitously in the mPFC, but not specifically in neurons nor in oligodendroglia, protected mice from the isolation rearing-induced cooperation defect. In addition to synapse integrity, Egr2 also regulated the development of oligodendroglia, specifically the transition from undifferentiated oligodendrocyte precursor cells to premyelinating oligodendrocytes. In conclusion, this study reveals the importance of mPFC Egr2 in the cooperative behavior that is modulated by social experience, and its unexpected role in oligodendrocyte development.
Identifiants
pubmed: 36646797
doi: 10.1038/s41684-022-01090-0
pii: 10.1038/s41684-022-01090-0
doi:
Substances chimiques
Egr2 protein, mouse
0
Early Growth Response Protein 2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-50Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81871117
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81801378
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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