Correlates of immunity to Group A Streptococcus: a pathway to vaccine development.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
17 Jan 2023
17 Jan 2023
Historique:
received:
29
07
2022
accepted:
06
12
2022
entrez:
17
1
2023
pubmed:
18
1
2023
medline:
18
1
2023
Statut:
epublish
Résumé
Understanding immunity in humans to Group A Streptococcus (Strep A) is critical for the development of successful vaccines to prevent the morbidity and mortality attributed to Strep A infections. Despite decades of effort, no licensed vaccine against Strep A exists and immune correlates of protection are lacking; a major impediment to vaccine development. In the absence of a vaccine, we can take cues from the development of natural immunity to Strep A in humans to identify immune correlates of protection. The age stratification of incidence of acute Strep A infections, peaking in young children and waning in early adulthood, coincides with the development of specific immune responses. Therefore, understanding the immune mechanisms involved in natural protection from acute Strep A infection is critical to identifying immune correlates to inform vaccine development. This perspective summarises the findings from natural infection studies, existing assays of immunity to Strep A, and highlights the gaps in knowledge to guide the development of Strep A vaccines and associated correlates of protection.
Identifiants
pubmed: 36650164
doi: 10.1038/s41541-022-00593-8
pii: 10.1038/s41541-022-00593-8
pmc: PMC9844947
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1Subventions
Organisme : Wellcome Trust (Wellcome)
ID : 215490/Z/19/Z
Organisme : Wellcome Trust (Wellcome)
ID : 215539/Z/19/Z
Informations de copyright
© 2023. The Author(s).
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