Infection-elicited microbiota promotes host adaptation to nutrient restriction.
Yersinia
carbohydrate
host metabolism
malnutrition
white adipose tissue
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
24 01 2023
24 01 2023
Historique:
entrez:
18
1
2023
pubmed:
19
1
2023
medline:
21
1
2023
Statut:
ppublish
Résumé
The microbiota performs multiple functions vital to host fitness, including defense against pathogens and adaptation to dietary changes. Yet, how environmental challenges shape microbiota resilience to nutrient fluctuation remains largely unexplored. Here, we show that transient gut infection can optimize host metabolism toward the usage of carbohydrates. Following acute infection and clearance of the pathogen, mice gained more weight as a result of white adipose tissue expansion. Concomitantly, previously infected mice exhibited enhanced carbohydrate (glucose) disposal and insulin sensitivity. This metabolic remodeling depended on alterations to the gut microbiota, with infection-elicited
Identifiants
pubmed: 36652484
doi: 10.1073/pnas.2214484120
pmc: PMC9942920
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2214484120Subventions
Organisme : NIGMS NIH HHS
ID : FI2 GM128736
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001115
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001132
Pays : United States
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