Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback.
behavioral state
cortico-thalamic feedback
dLGN
mouse
primary visual cortex
visual processing
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
01 03 2023
01 03 2023
Historique:
received:
24
10
2021
revised:
21
11
2022
accepted:
28
11
2022
pubmed:
19
1
2023
medline:
4
3
2023
entrez:
18
1
2023
Statut:
ppublish
Résumé
The behavioral state of a mammal impacts how the brain responds to visual stimuli as early as in the dorsolateral geniculate nucleus of the thalamus (dLGN), the primary relay of visual information to the cortex. A clear example of this is the markedly stronger response of dLGN neurons to higher temporal frequencies of the visual stimulus in alert as compared with quiescent animals. The dLGN receives strong feedback from the visual cortex, yet whether this feedback contributes to these state-dependent responses to visual stimuli is poorly understood. Here, we show that in male and female mice, silencing cortico-thalamic feedback profoundly reduces state-dependent differences in the response of dLGN neurons to visual stimuli. This holds true for dLGN responses to both temporal and spatial features of the visual stimulus. These results reveal that the state-dependent shift of the response to visual stimuli in an early stage of visual processing depends on cortico-thalamic feedback.
Identifiants
pubmed: 36653192
pii: JNEUROSCI.2124-21.2022
doi: 10.1523/JNEUROSCI.2124-21.2022
pmc: PMC10008059
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1540-1554Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025668
Pays : United States
Organisme : NEI NIH HHS
ID : K99 EY030415
Pays : United States
Informations de copyright
Copyright © 2023 Reinhold, Resulaj et al.
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