Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 01 2023
18 01 2023
Historique:
received:
22
04
2022
accepted:
28
12
2022
entrez:
18
1
2023
pubmed:
19
1
2023
medline:
21
1
2023
Statut:
epublish
Résumé
Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and blood pressure indices reveal multiple latent vascular factors, with independent contributions to cognition. In a population-based deep-phenotyping study (n = 708, age 18-88), path analysis revealed three latent vascular factors dissociating the autonomic nervous system response from two components of blood pressure. These three factors made unique and additive contributions to the variability in crystallized and fluid intelligence. The discrepancy in fluid relative to crystallized intelligence, indicative of cognitive decline, was associated with a latent vascular factor predominantly expressing pulse pressure. This suggests that higher pulse pressure is associated with cognitive decline from expected performance. The effect was stronger in older adults. Controlling pulse pressure may help to preserve cognition, particularly in older adults. Our findings highlight the need to better understand the multifactorial nature of vascular aging.
Identifiants
pubmed: 36653428
doi: 10.1038/s41598-022-27252-1
pii: 10.1038/s41598-022-27252-1
pmc: PMC9849401
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
978Subventions
Organisme : Medical Research Council
ID : MC_UU_00005/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T033371/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00030/8
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H008217/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220258
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00030/14
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00005/8
Pays : United Kingdom
Organisme : Medical Research Council
ID : SUAG/051 G101400
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00030/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105597119
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008983/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011194/1
Pays : United Kingdom
Investigateurs
Edward T Bullmore
(ET)
Andrew C Calder
(AC)
Rhodri Cusack
(R)
Tim Dalgleish
(T)
John Duncan
(J)
Fiona E Matthews
(FE)
William D Marslen-Wilson
(WD)
Meredith A Shafto
(MA)
Karen Campbell
(K)
Teresa Cheung
(T)
Simon Davis
(S)
Linda Geerligs
(L)
Anna McCarrey
(A)
Abdur Mustafa
(A)
Darren Price
(D)
David Samu
(D)
Jason R Taylor
(JR)
Matthias Treder
(M)
Janna van Belle
(J)
Nitin Williams
(N)
Daniel Mitchell
(D)
Simon Fisher
(S)
Else Eising
(E)
Ethan Knights
(E)
Lauren Bates
(L)
Tina Emery
(T)
Sharon Erzinçlioglu
(S)
Andrew Gadie
(A)
Sofia Gerbase
(S)
Stanimira Georgieva
(S)
Claire Hanley
(C)
Beth Parkin
(B)
David Troy
(D)
Tibor Auer
(T)
Marta Correia
(M)
Lu Gao
(L)
Emma Green
(E)
Rafael Henriques
(R)
Jodie Allen
(J)
Gillian Amery
(G)
Liana Amuntse
(L)
Anne Barcroft
(A)
Amanda Castle
(A)
Cheryl Dias
(C)
Jonathan Dowrick
(J)
Melissa Fair
(M)
Hayley Fisher
(H)
Anna Goulding
(A)
Adarsh Grewale
(A)
Geoff Hale
(G)
Andrew Hilton
(A)
Frances Johnson
(F)
Patricia Johnston
(P)
Thea Kavanagh-Williamson
(T)
Magdalena Kwasniewska
(M)
Alison McMinn
(A)
Kim Norman
(K)
Jessica Penrose
(J)
Fiona Roby
(F)
Diane Rowland
(D)
John Sargeant
(J)
Maggie Squire
(M)
Beth Stevens
(B)
Aldabra Stoddart
(A)
Cheryl Stone
(C)
Tracy Thompson
(T)
Ozlem Yazlik
(O)
Dan Barnes
(D)
Marie Dixon
(M)
Jaya Hillman
(J)
Joanne Mitchell
(J)
Laura Villis
(L)
Informations de copyright
© 2023. The Author(s).
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