Successful pediatric liver transplantation case with a positive SARS-CoV-2 test at the time of transplant.
SARS-CoV-2 infection
antiviral treatment
pediatric liver transplantation
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
ISSN: 1386-6346
Titre abrégé: Hepatol Res
Pays: Netherlands
ID NLM: 9711801
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
14
12
2022
received:
10
08
2022
accepted:
12
01
2023
medline:
20
1
2023
pubmed:
20
1
2023
entrez:
19
1
2023
Statut:
ppublish
Résumé
We report a successful liver transplantation (LT) in a child with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 3-year-old female patient with decompensated cirrhosis due to Alagille syndrome underwent a split LT with a left lateral segment graft. She had a history of SARS-CoV-2 infection 4 months before LT. She was exposed to SARS-CoV-2 after the decision for organ acceptance. We repeatedly confirmed the negative SARS-CoV-2 test by polymerase chain reaction (PCR) before LT. Liver transplantation was carried out in the negative pressure operational theater with full airborne, droplet, and contact precautions as the patient was considered to be within the incubation period of SARS-CoV-2. The SARS-CoV-2 PCR test became positive in the nasopharyngeal swab specimen at the operation. Remdesivir, the antiviral treatment, was held off due to potential hepatotoxicity and no exacerbation of COVID-19. She received tacrolimus and low-dose steroids per protocol. She remained SARS-CoV-2 positive on postoperative days (PODs) 1, 2, and 5. The presence of antibodies for SARS-CoV-2 at LT was confirmed later. On POD 53, she was discharged without any symptomatic infection. This case demonstrated that a positive SARS-CoV-2 result was not an absolute contraindication for a life-saving LT. Liver transplantation could be safely performed in a pediatric patient with asymptomatic COVID-19 and S-immunoglobulin G antibodies for SARS-CoV-2.
Types de publication
Case Reports
Langues
eng
Pagination
569-573Subventions
Organisme : Scientific Research Fund of the Ministry of Education and a Research Grant for Immunology, Allergy and Organ Transplant, Labor and Welfare, Japan
ID : 21591403, R3-1
Organisme : JSPS KAKENHI
ID : JP21K16392
Informations de copyright
© 2023 Japan Society of Hepatology.
Références
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