Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies.
Journal
ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411
Informations de publication
Date de publication:
13 Jan 2023
13 Jan 2023
Historique:
received:
28
10
2022
pmc-release:
28
12
2023
entrez:
19
1
2023
pubmed:
20
1
2023
medline:
20
1
2023
Statut:
epublish
Résumé
The advent of SARS-CoV-2, the causative agent of COVID-19, and its worldwide impact on global health, have provided the impetus for the development of effective countermeasures that can be deployed against the virus, including vaccines, monoclonal antibodies, and direct-acting antivirals (DAAs). Despite these efforts, the current paucity of DAAs has created an urgent need for the creation of an enhanced and diversified portfolio of broadly acting agents with different mechanisms of action that can effectively abrogate viral infection. SARS-CoV-2 3C-like protease (3CL
Identifiants
pubmed: 36654747
doi: 10.1021/acsptsci.2c00206
pmc: PMC9841783
doi:
Types de publication
Journal Article
Langues
eng
Pagination
181-194Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM133893
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR024664
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM110761
Pays : United States
Organisme : NIH HHS
ID : S10 OD030394
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI161085
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130092
Pays : United States
Informations de copyright
© 2022 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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