Phox2B is a sensitive and reliable marker of paraganglioma-Phox2B immunohistochemistry in diagnosis of neuroendocrine neoplasms.
Chromaffin cell
GATA3
Neuroendocrine neoplasms
Olfactory neuroblastoma
Paraganglioma
Phox2B
Well differentiated neuroendocrine tumours
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
07
09
2022
accepted:
09
01
2023
revised:
14
12
2022
medline:
4
4
2023
pubmed:
20
1
2023
entrez:
19
1
2023
Statut:
ppublish
Résumé
Phox2B is a transcription factor responsible for chromaffin cell phenotype. Although it is used routinely for diagnosis of neuroblastoma, previous reports concerning its utility in the diagnosis of neuroendocrine neoplasms have been conflicting. We assessed Phox2b immunoreactivity in different neuroendocrine neoplasms. Tissue microarrays or whole sections of 36 paragangliomas (PGs), 91 well-differentiated neuroendocrine tumours of different organs (WDNETs), 31 neuroendocrine carcinomas (NECs), and 6 olfactory neuroblastomas (ONBs) were stained with Phox2B antibody (EP312) and GATA3. The percentage of positive cells and intensity was analysed using H-score. Phox2B immunoreactivity was seen in 97.2% (35/36) PGs, 11% (10/91) WDNETs, 9.7% (3/31) NECs, and 16.7% (1/6) ONBs. PGs were significantly more often positive (p < 0.001, χ
Identifiants
pubmed: 36656393
doi: 10.1007/s00428-023-03490-0
pii: 10.1007/s00428-023-03490-0
doi:
Substances chimiques
Biomarkers, Tumor
0
Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
679-686Subventions
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NV19-01-00435
Organisme : BBMRI-CZ
ID : LM2018125
Organisme : European Regional Development Fund-Project BBMRI-CZ.: Biobank network
ID : EF16_013/0001674
Organisme : Univerzita Karlova v Praze
ID : DIAG
Organisme : Univerzita Karlova v Praze
ID : METD
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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