Targets and cross-reactivity of human T cell recognition of Common Cold Coronaviruses.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
05 Jan 2023
Historique:
entrez: 19 1 2023
pubmed: 20 1 2023
medline: 20 1 2023
Statut: epublish

Résumé

The Coronavirus (CoV) family includes a variety of viruses able to infect humans. Endemic CoVs that can cause common cold belong to the alphaCoV and betaCoV genera, with the betaCoV genus also containing subgenera with zoonotic and pandemic concern, including sarbecoCoV (SARS-CoV and SARS-CoV-2) and merbecoCoV (MERS-CoV). It is therefore warranted to explore pan-CoV vaccine concepts, to provide adaptive immune protection against new potential CoV outbreaks, particularly in the context of betaCoV sub lineages. To explore the feasibility of eliciting CD4

Identifiants

pubmed: 36656777
doi: 10.1101/2023.01.04.522794
pmc: PMC9844015
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : 75N93019C00065
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00076
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI168347
Pays : United States
Organisme : NIAID NIH HHS
ID : R25 AI147376
Pays : United States

Commentaires et corrections

Type : UpdateIn

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Auteurs

Alison Tarke (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Department of Experimental Medicine and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, 16132, Italy.

Yun Zhang (Y)

J. Craig Venter Institute, La Jolla, CA 92037, USA.

Nils Methot (N)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

Tara M Narowski (TM)

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7290, USA.

Elizabeth Phillips (E)

Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.

Simon Mallal (S)

Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.

April Frazier (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

Gilberto Filaci (G)

Center of Excellence for Biomedical Research, Department of Internal Medicine, University of Genoa, Genoa 16132, Italy.
Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa 16132, Italy.

Daniela Weiskopf (D)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

Jennifer M Dan (JM)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.

Lakshmanane Premkumar (L)

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7290, USA.

Richard H Scheuermann (RH)

J. Craig Venter Institute, La Jolla, CA 92037, USA.
Department of Pathology, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
These authors contributed equally.

Alessandro Sette (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
These authors contributed equally.

Alba Grifoni (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
These authors contributed equally.
Lead Contact.

Classifications MeSH