Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 01 2023
19 01 2023
Historique:
received:
20
08
2022
accepted:
04
01
2023
entrez:
19
1
2023
pubmed:
20
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
Recent rises in incident tuberculosis (TB) cases in Paraguay and the increasing concentration of TB within prisons highlight the urgency of targeting strategies to interrupt transmission and prevent new infections. However, whether specific cities or carceral institutions play a disproportionate role in transmission remains unknown. We conducted prospective genomic surveillance, sequencing 471 Mycobacterium tuberculosis complex genomes, from inside and outside prisons in Paraguay's two largest urban areas, Asunción and Ciudad del Este, from 2016 to 2021. We found genomic evidence of frequent recent transmission within prisons and transmission linkages spanning prisons and surrounding populations. We identified a signal of frequent M. tuberculosis spread between urban areas and marked recent population size expansion of the three largest genomic transmission clusters. Together, our findings highlight the urgency of strengthening TB control programs to reduce transmission risk within prisons in Paraguay, where incidence was 70 times that outside prisons in 2021.
Identifiants
pubmed: 36658111
doi: 10.1038/s41467-023-35813-9
pii: 10.1038/s41467-023-35813-9
pmc: PMC9849832
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
303Subventions
Organisme : NIAID NIH HHS
ID : K01 AI173385
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130058
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI149620
Pays : United States
Informations de copyright
© 2023. The Author(s).
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