Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 01 2023
19 01 2023
Historique:
received:
04
02
2022
accepted:
01
11
2022
entrez:
19
1
2023
pubmed:
20
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). We characterize 58 primary human RS samples by genome-wide DNA methylation and whole-transcriptome profiling. Our comprehensive approach determines RS DNA methylation profile and unravels a CLL epigenetic imprint, allowing CLL-RS clonal relationship assessment without the need of the initial CLL tumor DNA. DNA methylation- and transcriptomic-based classifiers were developed, and testing on landmark DLBCL datasets identifies a poor-prognosis, activated B-cell-like DLBCL subset in 111/1772 samples. The classification robustly identifies phenotypes very similar to RS with a specific genomic profile, accounting for 4.3-8.3% of de novo DLBCLs. In this work, RS multi-omics characterization determines oncogenic mechanisms, establishes a surrogate marker for CLL-RS clonal relationship, and provides a clinically relevant classifier for a subset of primary "RS-type DLBCL" with unfavorable prognosis.
Identifiants
pubmed: 36658118
doi: 10.1038/s41467-022-34642-6
pii: 10.1038/s41467-022-34642-6
pmc: PMC9852595
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
309Investigateurs
Stephan Bernhart
(S)
Informations de copyright
© 2023. The Author(s).
Références
Mol Neurobiol. 2019 Feb;56(2):892-906
pubmed: 29804229
Leukemia. 2015 Mar;29(3):598-605
pubmed: 25151957
Mol Biosyst. 2016 Feb;12(2):477-9
pubmed: 26661513
Br J Haematol. 2013 Oct;163(2):194-204
pubmed: 23961875
Nat Med. 2018 May;24(5):679-690
pubmed: 29713087
Blood. 2014 Mar 13;123(11):1699-708
pubmed: 24385541
J Neurooncol. 2009 Mar;92(1):23-31
pubmed: 19011762
Nat Protoc. 2009;4(8):1184-91
pubmed: 19617889
Nat Med. 2022 Aug;28(8):1662-1671
pubmed: 35953718
Bioinformatics. 2018 Jun 15;34(12):2142-2143
pubmed: 29420690
Neoplasia. 2021 Jan;23(1):140-148
pubmed: 33316538
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
Nat Genet. 2015 Jul;47(7):746-56
pubmed: 26053498
Nucleic Acids Res. 2019 Jan 8;47(D1):D745-D751
pubmed: 30407521
Blood. 2011 Mar 24;117(12):3391-401
pubmed: 21266718
Nature. 2000 Feb 3;403(6769):503-11
pubmed: 10676951
Am J Surg Pathol. 2007 Oct;31(10):1605-14
pubmed: 17895764
N Engl J Med. 2018 Apr 12;378(15):1396-1407
pubmed: 29641966
Hematol Oncol. 2010 Jun;28(2):62-7
pubmed: 20014148
Nat Genet. 2012 Nov;44(11):1236-42
pubmed: 23064414
Blood. 2019 Aug 8;134(6):534-547
pubmed: 31010847
Epigenetics Chromatin. 2015 Jan 27;8:6
pubmed: 25972926
Blood. 2021 Sep 23;138(12):1053-1066
pubmed: 33900379
Cancer Discov. 2014 Mar;4(3):348-61
pubmed: 24356097
Cancer Cell. 2020 Apr 13;37(4):551-568.e14
pubmed: 32289277
Blood. 2013 Oct 10;122(15):2673-82
pubmed: 24004666
Front Immunol. 2020 Dec 14;11:594841
pubmed: 33381116
Blood. 2018 Jun 21;131(25):2745-2760
pubmed: 29540348
Am J Hematol. 2021 Sep 1;96(9):E311-E314
pubmed: 34000073
Cancer Cell. 2016 Nov 14;30(5):806-821
pubmed: 27846393
Nat Rev Dis Primers. 2017 Feb 09;3:17008
pubmed: 28179635
Brain Pathol. 2020 May;30(3):465-478
pubmed: 31561286
Cancer Cell. 2021 Dec 13;39(12):1643-1653.e3
pubmed: 34739844
Nat Genet. 2015 Nov;47(11):1316-1325
pubmed: 26437030
Leukemia. 2021 Jul;35(7):2002-2016
pubmed: 33953289
N Engl J Med. 2008 Nov 27;359(22):2313-23
pubmed: 19038878
BMC Bioinformatics. 2020 Jun 29;21(1):268
pubmed: 32600298
Nature. 2009 Sep 10;461(7261):199-205
pubmed: 19741700
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
Nat Cancer. 2020 Nov;1(11):1066-1081
pubmed: 34079956
Nat Biotechnol. 2015 Mar;33(3):290-5
pubmed: 25690850
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Nat Commun. 2015 Apr 20;6:6921
pubmed: 25891015
Genome Biol. 2010;11(3):R25
pubmed: 20196867
Histopathology. 2016 Dec;69(6):1066-1076
pubmed: 27345622
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9991-6
pubmed: 12900505
EBioMedicine. 2019 Oct;48:58-69
pubmed: 31648986
Blood. 2010 Nov 18;116(20):e81-9
pubmed: 20610814
Genomics. 2011 Oct;98(4):288-95
pubmed: 21839163
J Natl Cancer Inst. 2002 Jan 2;94(1):26-32
pubmed: 11773279
Nucleic Acids Res. 2012 Dec;40(22):11339-51
pubmed: 23074194
Nucleic Acids Res. 2021 Jan 8;49(D1):D1302-D1310
pubmed: 33196847
Development. 2017 Aug 1;144(15):2719-2729
pubmed: 28765213
Cell. 2017 Oct 5;171(2):481-494.e15
pubmed: 28985567
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Bioinformatics. 2007 Jul 15;23(14):1846-7
pubmed: 17496320
Cancer Cell. 2015 Sep 14;28(3):329-42
pubmed: 26373280
J Exp Med. 2013 Oct 21;210(11):2273-88
pubmed: 24127483
Nat Genet. 2016 Mar;48(3):253-64
pubmed: 26780610
Blood. 2021 Jun 17;137(24):3378-3389
pubmed: 33786583
Bioinformatics. 2016 Jan 15;32(2):286-8
pubmed: 26424855
Cell Death Dis. 2019 Aug 8;10(8):596
pubmed: 31395852
Blood. 2021 Jun 17;137(24):3365-3377
pubmed: 33512452
Blood. 2021 May 20;137(20):2800-2816
pubmed: 33206936
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Cancer Res. 2018 Jul 1;78(13):3413-3420
pubmed: 29735551
Cell. 2018 Oct 4;175(2):598-599
pubmed: 30290144
Oncogene. 2012 Nov 8;31(45):4798-802
pubmed: 22249250
Nucleic Acids Res. 2019 Jul 2;47(W1):W234-W241
pubmed: 30931480
Genome Biol. 2012 Jun 15;13(6):R44
pubmed: 22703947
Nat Med. 2018 Jun;24(6):868-880
pubmed: 29785028