Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 01 2023
19 01 2023
Historique:
received:
16
02
2022
accepted:
06
01
2023
entrez:
19
1
2023
pubmed:
20
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
We use data-driven physical simulations to study the three-dimensional architecture of the Aedes aegypti genome. Hi-C maps exhibit both a broad diagonal and compartmentalization with telomeres and centromeres clustering together. Physical modeling reveals that these observations correspond to an ensemble of 3D chromosomal structures that are folded over and partially condensed. Clustering of the centromeres and telomeres near the nuclear lamina appears to be a necessary condition for the formation of the observed structures. Further analysis of the mechanical properties of the genome reveals that the chromosomes of Aedes aegypti, by virtue of their atypical structural organization, are highly sensitive to the deformation of the nuclei. This last finding provides a possible physical mechanism linking mechanical cues to gene regulation.
Identifiants
pubmed: 36658127
doi: 10.1038/s41467-023-35909-2
pii: 10.1038/s41467-023-35909-2
pmc: PMC9852290
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
326Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM146852
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG009375
Pays : United States
Organisme : NHGRI NIH HHS
ID : RM1 HG011016
Pays : United States
Informations de copyright
© 2023. The Author(s).
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