Thyroglobulin expression, Ki-67 index, and lymph node ratio in the prognostic assessment of papillary thyroid cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 01 2023
19 01 2023
Historique:
received:
15
07
2022
accepted:
05
01
2023
entrez:
19
1
2023
pubmed:
20
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
The clinical significance of thyroglobulin (Tg) expression in papillary thyroid cancer (PTC) has not been systematically explored in relation to the Ki-67 index, lymph node ratio (LNR), or other conventional prognostic predictors. In this retrospective study of 327 patients with PTC, we investigated the immunohistochemical expression of Tg in both primary tumors and their matching lymph node metastases in relation to the Ki-67 index, LNR, and clinical data. Tumoral Tg immunoreactivity was inversely correlated to the Ki-67 index and tumor recurrence. The Ki-67 index was higher in lymph node metastases (mean 4%) than in the primary tumors (mean 3%). Reduced Tg expression, estimated as 0-25% Tg positive tumor cells, was more common in lymph node metastases compared to primary tumors. In addition to advanced metastatic burden (defined as N1b stage and LNR ≥ 21%), low Tg expression (0-25% positive tumor cells) in lymph node metastases had a significant prognostic impact with shorter recurrence-free survival. These findings support the potential value of histopathological assessment of Tg expression and Ki-67 index in lymph node metastases as complementary predictors to anticipate the prognosis of PTC patients better.
Identifiants
pubmed: 36658256
doi: 10.1038/s41598-023-27684-3
pii: 10.1038/s41598-023-27684-3
pmc: PMC9852547
doi:
Substances chimiques
Thyroglobulin
9010-34-8
Ki-67 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1070Informations de copyright
© 2023. The Author(s).
Références
PLoS One. 2020 Feb 24;15(2):e0229264
pubmed: 32092093
Cancers (Basel). 2021 Jul 20;13(14):
pubmed: 34298840
Eur J Endocrinol. 2006 Jun;154(6):787-803
pubmed: 16728537
Thyroid. 2020 Jan;30(1):42-56
pubmed: 31668133
Surgery. 2018 Jan;163(1):118-123
pubmed: 29128176
Nucl Med Mol Imaging. 2016 Dec;50(4):329-336
pubmed: 27994688
Virchows Arch A Pathol Anat Histopathol. 1982;398(1):87-99
pubmed: 6819704
J Clin Endocrinol Metab. 2017 Jun 1;102(6):1898-1907
pubmed: 28323937
Br J Cancer. 2014 Apr 2;110(7):1688-97
pubmed: 24619074
Biochim Biophys Acta. 1981 Aug 31;651(1):37-50
pubmed: 7025905
Am J Surg Pathol. 1999 Jun;23(6):678-85
pubmed: 10366150
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Head Neck. 2016 Dec;38(12):1772-1779
pubmed: 27299298
Transl Oncol. 2015 Apr;8(2):119-25
pubmed: 25926078
Thyroid. 2019 Oct;29(10):1425-1437
pubmed: 31298630
J Laryngol Otol. 2018 Jan;132(1):8-13
pubmed: 29122022
Surgery. 2006 Dec;140(6):899-905; discussion 905-6
pubmed: 17188136
Mod Pathol. 2001 Apr;14(4):289-96
pubmed: 11301345
Cancer Lett. 2016 Sep 28;380(1):359-68
pubmed: 26791236
Clin Breast Cancer. 2015 Oct;15(5):307-12
pubmed: 25922284
FEBS Lett. 2014 Aug 1;588(15):2422-7
pubmed: 24931375
Virchows Arch A Pathol Anat Histopathol. 1982;398(2):221-8
pubmed: 6187120
J Otolaryngol Head Neck Surg. 2022 Feb 22;51(1):7
pubmed: 35193694
J Pathol Transl Med. 2018 Sep;52(5):331-338
pubmed: 30157618
Hum Pathol. 2011 Dec;42(12):1823-32
pubmed: 21683981
Gland Surg. 2015 Feb;4(1):52-62
pubmed: 25713780
J BUON. 2019 Jul-Aug;24(4):1626-1637
pubmed: 31646818
J Nucl Med. 2005 Jul;46(7):1164-70
pubmed: 16000286
Eur J Nucl Med Mol Imaging. 2008 Oct;35(10):1941-59
pubmed: 18670773
World J Surg. 2021 Jul;45(7):2155-2164
pubmed: 33825961
F1000Res. 2018 Aug 1;7:
pubmed: 30135716
Histopathology. 1988 Jul;13(1):43-54
pubmed: 3061922
Cancer. 2004 Oct 15;101(8):1803-8
pubmed: 15386300
Nat Rev Endocrinol. 2011 Aug 30;7(10):569-80
pubmed: 21878896
Ann Oncol. 2011 Jul;22(7):1554-1560
pubmed: 21242587
Thyroid. 2009 Oct;19(10):1053-9
pubmed: 19772423
Clin Chim Acta. 2008 Feb;388(1-2):15-21
pubmed: 18060877
Transl Lung Cancer Res. 2020 Oct;9(5):2245-2254
pubmed: 33209647
BJU Int. 2017 Sep;120(3):329-336
pubmed: 27797436
Thyroid. 2016 Jan;26(1):1-133
pubmed: 26462967
Exp Oncol. 2019 Dec;41(4):342-345
pubmed: 31868336
BMC Cancer. 2019 Jun 17;19(1):591
pubmed: 31208403
Endocr J. 2015;62(1):1-12
pubmed: 25195708
Ann Diagn Pathol. 2021 Oct;54:151793
pubmed: 34425503
Oral Oncol. 2018 Mar;78:80-86
pubmed: 29496063
Nature. 2013 Sep 19;501(7467):328-37
pubmed: 24048065
J Thorac Oncol. 2009 Oct;4(10):1212-20
pubmed: 19687761