Conditioning of microvascular venous flaps in rats.

Rats Animals Veins Vascular Surgical Procedures Arteries Fluorescein Angiography Free Tissue Flaps Graft Survival

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
19 01 2023
Historique:
received: 17 08 2021
accepted: 12 01 2023
entrez: 19 1 2023
pubmed: 20 1 2023
medline: 24 1 2023
Statut: epublish

Résumé

Venous-only perfusion flaps have not been used widely because of the associated high failure rate. Tissue conditioning offers a broad scope of techniques that can be applied pre-, peri-, or postoperatively to promote the adaptation of the affected tissue to any subsequent stress. This study aimed to assess the survival rates associated with a pure venous perfusion flap and investigate whether the timing of the vascular conditioning can affect free flap survival. Forty-four rats were included in the experiment. Group I underwent veno-arterial anastomoses with epigastric graft with pure venous perfusion without tissue conditioning. Groups II and III were pretreated for 7 or 14 days with ischemic conditioning. These groups were compared with a control group (group IV) of conventionally perfused flaps. After the initial surgery, all flaps were assessed clinically, photometrically, and by indocyanine green videoangiography. The flap success rates were 0% in group I, 49.97% ± 24.34% in group II, and 64.95% ± 20.36% in group III. The control group showed an overall survival of 89.3% ± 6.51%. With suitable conditioning, pure venous blood supply can provide adequate perfusion in the rat epigastric flap model. The timing of vascular conditioning appears to be critical for flap survival.

Identifiants

DOI: 10.1038/s41598-023-28054-9 PMID: 36658326 PMC: PMC9852422
pubmed: 36658326
doi: 10.1038/s41598-023-28054-9
pii: 10.1038/s41598-023-28054-9
pmc: PMC9852422
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1029

Informations de copyright

© 2023. The Author(s).

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Auteurs

Christian Heiliger (C)

Department of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum Rechts Der Isar, Munich, Germany. heiliger.ch@gmail.com.

Lucas M Ritschl (LM)

Department of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum Rechts Der Isar, Munich, Germany.

Andreas M Fichter (AM)

Department of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum Rechts Der Isar, Munich, Germany.

Lukas K Postl (LK)

Medical Faculty, Johannes Kepler University Linz, Linz, Austria.

Anastasios Kanatas (A)

St James Institute of Oncology and Leeds Dental Institute, Leeds Teaching Hospitals, Leeds, UK.

Klaus Dietrich Wolff (KD)

Department of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum Rechts Der Isar, Munich, Germany.

Thomas Mücke (T)

Department of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum Rechts Der Isar, Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Conditioning of microvascular venous flaps in rats.
questionsmedicales.fr › Eucaryotes › Animaux › Conditioning of microvascular venous flaps in rats.
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Veines › Conditioning of microvascular venous flaps in rats.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie cardiovasculaire › Procédures de chirurgie vasculaire › Conditioning of microvascular venous flaps in rats.
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Conditioning of microvascular venous flaps in rats.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic ophtalmologique › Angiographie fluorescéinique › Conditioning of microvascular venous flaps in rats.
questionsmedicales.fr › Équipement et fournitures › Reconstructions chirurgicales › Lambeaux chirurgicaux › Lambeaux tissulaires libres › Conditioning of microvascular venous flaps in rats.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Conditioning of microvascular venous flaps in rats.