Liver Damage and microRNAs: An Update.
drug-induced liver injury
early biomarkers
hepatitis B virus infection
microRNAs
Journal
Current issues in molecular biology
ISSN: 1467-3045
Titre abrégé: Curr Issues Mol Biol
Pays: Switzerland
ID NLM: 100931761
Informations de publication
Date de publication:
23 Dec 2022
23 Dec 2022
Historique:
received:
13
11
2022
revised:
12
12
2022
accepted:
20
12
2022
entrez:
20
1
2023
pubmed:
21
1
2023
medline:
21
1
2023
Statut:
epublish
Résumé
One of the major organs in the body with multiple functions is the liver. It plays a central role in the transformation of macronutrients and clearance of chemicals and drugs. The serum biomarkers often used to indicate liver damage are not specifically for drug-induced liver injury (DILI) or liver injury caused by other xenobiotics, nor for viral infection. In this case, microRNAs (miRNAs) could play an exciting role as biomarkers of specific liver damage. In this review, we aimed to update the current literature on liver damage induced by drugs, as acute conditions and viral infections mediated by the hepatitis B virus (HBV) linked these two conditions to advanced research, with a focus on microRNAs as early biomarkers for liver damage. The undoubtable evidence that circulating miR-122 could be used as a human biomarker of DILI came from several studies in which a strong increase of it was linked with the status of liver function. In infancy, there is the possibility of an early miRNA detection for hepatitis B virus infection, but there are a lack of solid models for studying the HVB molecular mechanism of infection in detail, even if miRNAs do hold unrealized potential as biomarkers for early detection of hepatitis B virus infection mediated by HBV.
Identifiants
pubmed: 36661492
pii: cimb45010006
doi: 10.3390/cimb45010006
pmc: PMC9857663
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
78-91Références
Clin Chem. 2010 Dec;56(12):1830-8
pubmed: 20930130
Cell Metab. 2006 Feb;3(2):87-98
pubmed: 16459310
Dig Dis Sci. 2013 May;58(5):1415-21
pubmed: 23212393
Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):
pubmed: 33495342
Clin Gastroenterol Hepatol. 2015 Jul;13(7):1328-1336.e2
pubmed: 25528012
Am J Gastroenterol. 2007 Mar;102(3):558-62; quiz 693
pubmed: 17156142
Virol J. 2018 Apr 23;15(1):73
pubmed: 29685146
PLoS One. 2012;7(5):e37395
pubmed: 22624025
Antioxidants (Basel). 2019 Aug 02;8(8):
pubmed: 31382449
World J Gastroenterol. 2020 Mar 21;26(11):1113-1127
pubmed: 32231417
Toxicol Pathol. 2013 Jul;41(5):795-804
pubmed: 23143187
JHEP Rep. 2020 Sep 06;2(6):100179
pubmed: 33134908
Drug Saf. 2016 Aug;39(8):749-54
pubmed: 27189593
Br J Pharmacol. 2004 Sep;143(1):1-2
pubmed: 15345657
South Med J. 2014 Feb;107(2):107-13
pubmed: 24926677
Hepatology. 2002 Aug;36(2):451-5
pubmed: 12143055
Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8
pubmed: 22285215
Curr Biol. 2002 Apr 30;12(9):735-9
pubmed: 12007417
Nat Rev Endocrinol. 2010 Aug;6(8):416
pubmed: 20681069
J Hepatol. 2018 Dec;69(6):1317-1325
pubmed: 30138689
Cancer Lett. 2014 Apr 10;345(2):216-22
pubmed: 23981576
J Biol Chem. 2010 Feb 12;285(7):4415-22
pubmed: 20018894
Genes Dev. 2009 Jun 1;23(11):1313-26
pubmed: 19487572
Gastroenterology. 2013 Jun;144(7):1419-25, 1425.e1-3; quiz e19-20
pubmed: 23419359
J Hepatol. 1990 Sep;11(2):272-6
pubmed: 2254635
Life (Basel). 2022 Oct 22;12(11):
pubmed: 36362837
Gastroenterology. 2015 Jun;148(7):1340-52.e7
pubmed: 25754159
Drug Saf. 2001;24(7):503-12
pubmed: 11444723
Am J Med. 1992 Jul;93(1):102-4
pubmed: 1626557
Liver Int. 2016 Apr;36(4):603-9
pubmed: 26601797
Antivir Ther. 2012;17(7):1243-53
pubmed: 22997154
Liver Int. 2014 Feb;34(2):281-95
pubmed: 23834235
Diabetologia. 2012 Jul;55(7):2032-43
pubmed: 22476949
Hepatology. 2005 Dec;42(6):1364-72
pubmed: 16317692
Clin Gastroenterol Hepatol. 2017 Jan;15(1):103-112.e2
pubmed: 27311619
Dig Dis Sci. 2017 Dec;62(12):3596-3604
pubmed: 29119413
Drug Saf. 2007;30(4):277-94
pubmed: 17408305
PLoS One. 2014 Oct 28;9(10):e110782
pubmed: 25350115
J Virol. 2017 Apr 28;91(10):
pubmed: 28148795
Microbiol Mol Biol Rev. 2000 Mar;64(1):51-68
pubmed: 10704474
J Infect Dis. 2017 May 1;215(9):1421-1429
pubmed: 28368488
Cell. 2011 Sep 30;147(1):81-94
pubmed: 21962509
Hepatology. 2010 Dec;52(6):2065-76
pubmed: 20949552
Br Med Bull. 1990 Apr;46(2):354-67
pubmed: 2198991
Biochem Pharmacol. 2010 Apr 1;79(7):1045-52
pubmed: 19945440
Am J Gastroenterol. 2020 Feb;115(2):251-261
pubmed: 31789632
Int J Mol Sci. 2021 Sep 08;22(18):
pubmed: 34575884
Gastroenterology. 2005 Aug;129(2):512-21
pubmed: 16083708
Br Heart J. 1988 Jun;59(6):690-1
pubmed: 3395527
Annu Rev Biochem. 1987;56:651-93
pubmed: 3039907
Hepatology. 2008 Dec;48(6):1810-20
pubmed: 19030170
Dis Mon. 2014 Feb;60(2):55-104
pubmed: 24507900
J Clin Invest. 2011 Apr;121(4):1386-96
pubmed: 21364282
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4402-7
pubmed: 19246379
PLoS One. 2012;7(2):e30250
pubmed: 22363424
J Biol Chem. 2008 Apr 11;283(15):9674-80
pubmed: 18268015
Hepatology. 2011 Nov;54(5):1767-76
pubmed: 22045675
Hepatology. 2009 Feb;49(2):618-26
pubmed: 19127519
World J Gastroenterol. 2012 Jun 14;18(22):2798-804
pubmed: 22719188
Biomark Med. 2013 Apr;7(2):307-15
pubmed: 23547824
Hepatology. 2012 Nov;56(5):1946-57
pubmed: 22684891
Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4
pubmed: 18955056
Clin Pharmacokinet. 2021 May;60(5):585-601
pubmed: 33723723
N Engl J Med. 1976 Nov 25;295(22):1232-6
pubmed: 790185
Microb Pathog. 1989 May;6(5):311-25
pubmed: 2671579
J Hepatol. 1988 Aug;7(1):21-33
pubmed: 3053890
AAPS J. 2006 Feb 03;8(1):E48-54
pubmed: 16584133
Am J Med Sci. 1975 Sep-Oct;270(2):212-27
pubmed: 799469
Ann Intern Med. 2002 Dec 17;137(12):947-54
pubmed: 12484709
Toxicol Appl Pharmacol. 2021 Feb 1;412:115389
pubmed: 33385404
Gastroenterology. 2021 Dec;161(6):1982-1997.e11
pubmed: 34425095
Microrna. 2019;8(2):116-126
pubmed: 30474543
Sci Rep. 2015 Jun 26;5:11602
pubmed: 26111969
Arch Toxicol. 2020 Oct;94(10):3381-3407
pubmed: 32852569
Mol Pharmacol. 2012 Sep;82(3):529-40
pubmed: 22723340
Science. 2010 Jun 18;328(5985):1570-3
pubmed: 20466885
J Nutr. 2012 Sep;142(9):1659-65
pubmed: 22833655
J Virol. 1984 Nov;52(2):396-402
pubmed: 6492255
Hepatology. 2014 Oct;60(4):1399-408
pubmed: 25043597
Hepatology. 2017 Jan;65(1):363-373
pubmed: 27677775
J Immunol. 1990 Nov 15;145(10):3442-9
pubmed: 2230128
Lancet. 2014 Dec 6;384(9959):2053-63
pubmed: 24954675
J Virol. 1990 Feb;64(2):613-20
pubmed: 2153228
Sci Rep. 2017 Nov 15;7(1):15658
pubmed: 29142236
Int J Mol Sci. 2021 Dec 25;23(1):
pubmed: 35008650
Pharm Res. 2014 Mar;31(3):780-94
pubmed: 24078287
Hepatology. 2013 Aug;58(2):777-87
pubmed: 23390034
Am J Gastroenterol. 2021 May 1;116(5):878-898
pubmed: 33929376
Ann Pharmacother. 1995 Sep;29(9):875-8
pubmed: 8547737
Hepatology. 2009 May;49(5 Suppl):S13-21
pubmed: 19399811
Clin Liver Dis. 2013 Nov;17(4):507-18, vii
pubmed: 24099014
Medicine (Baltimore). 2021 Dec 17;100(50):e27941
pubmed: 34918643
Hepatology. 1989 Feb;9(2):322-7
pubmed: 2643549
Cell Signal. 2013 Jun;25(6):1429-37
pubmed: 23499676
Nat Rev Drug Discov. 2005 Jun;4(6):489-99
pubmed: 15931258
J Mol Endocrinol. 2021 Nov 26;68(1):35-49
pubmed: 34723832
Clin Gastroenterol Hepatol. 2015 Feb;13(2):369-376.e3
pubmed: 25111234
Pharmaceuticals (Basel). 2021 Dec 02;14(12):
pubmed: 34959658
Exp Ther Med. 2016 Oct;12(4):2606-2616
pubmed: 27703513
J Intern Med. 2007 Sep;262(3):393-401
pubmed: 17697161
J Hepatol. 1991;13 Suppl 4:S90-2
pubmed: 1822521
Clin Liver Dis. 2012 May;16(2):231-45
pubmed: 22541696
Chin Med J (Engl). 2018 Aug 05;131(15):1813-1818
pubmed: 30058578
Clin Gastroenterol Hepatol. 2013 May;11(5):558-564.e3
pubmed: 23333219
Clin Gastroenterol Hepatol. 2011 Jun;9(6):517-523.e3
pubmed: 21356330
Mol Med Rep. 2012 Jun;5(6):1428-32
pubmed: 22427142