Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans.
Aging
C. elegans
F26A3.4
Healthspan
Locomotion
WorMotel
Journal
Biogerontology
ISSN: 1573-6768
Titre abrégé: Biogerontology
Pays: Netherlands
ID NLM: 100930043
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
23
07
2022
accepted:
25
11
2022
pubmed:
21
1
2023
medline:
15
3
2023
entrez:
20
1
2023
Statut:
ppublish
Résumé
Understanding how we can age healthily is a challenge at the heart of biogerontological interest. Whereas myriad genes are known to affect the lifespan of model organisms, effects of such interventions on healthspan-the period of life where an animal is considered healthy, rather than merely alive-are less clear. To understand relationships between life- and healthspan, in recent years several platforms were developed with the purpose of assessing both readouts simultaneously. We here relied on one such platform, the WorMotel, to study effects of adulthood-restricted knock-down of 130 Caenorhabditis elegans genes on the locomotive health of the animals along their lifespans. We found that knock-down of six genes affected healthspan while lifespan remained unchanged. For two of these, F26A3.4 and chn-1, knock-down resulted in an improvement of healthspan. In follow-up experiments we showed that knockdown of F26A3.4 indeed improves locomotive health and muscle structure at old age.
Identifiants
pubmed: 36662373
doi: 10.1007/s10522-022-10009-8
pii: 10.1007/s10522-022-10009-8
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-233Subventions
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
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