Indirectly determined reference intervals for automated white blood cell differentials of pediatric patients in Berlin and Brandenburg.
data mining
differential blood count
hematology
indirect reference interval
indirect reference range
pediatric
white blood cell differential
Journal
Clinical chemistry and laboratory medicine
ISSN: 1437-4331
Titre abrégé: Clin Chem Lab Med
Pays: Germany
ID NLM: 9806306
Informations de publication
Date de publication:
25 05 2023
25 05 2023
Historique:
received:
09
11
2022
accepted:
12
01
2023
medline:
24
4
2023
pubmed:
21
1
2023
entrez:
20
1
2023
Statut:
epublish
Résumé
Establishing direct reference intervals for pediatric patients is a costly, challenging, and time-consuming enterprise. Indirectly established reference intervals can help to ameliorate this situation. It was our objective to establish population-specific reference intervals for automated white blood cell differentials via data mining and non-parametric percentile method. Blood counts and automated white blood cell differentials of patients aged 0 days to 18 years, performed from the 1st of January 2018 until the 30th of June 2022, were identified in our laboratory information system. Reference intervals were established in accordance with IFCC and CLSI recommendations as well as the propositions by Haeckel et al. Initially, 47,173 blood counts on our SYSMEX XN-9000 were identified. 11,707 data sets were excluded, leaving 35,466 sample sets for analysis. Of these, 17,616 contained automated white blood cell differentials. Due to insufficient patient numbers, no reference intervals for automated white blood cell differentials could be established for children aged <7 months. In comparison to the corresponding reference intervals published by Herklotz et al., reference intervals determined by us showed relevant differences throughout all age groups. The combination of non-parametric percentile method and the propositions by Haeckel et al. utilizing conscientious data mining appears to be potent alternative to direct reference interval determination.
Identifiants
pubmed: 36669090
pii: cclm-2022-1265
doi: 10.1515/cclm-2022-1265
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1116-1122Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
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