Concise Review: Bioengineering of Limbal Stem Cell Niche.
LSCD
bioengineering
limbal niche
limbal stem cell deficiency
limbal stem cell niche
limbal stem cells
niche restoration
Journal
Bioengineering (Basel, Switzerland)
ISSN: 2306-5354
Titre abrégé: Bioengineering (Basel)
Pays: Switzerland
ID NLM: 101676056
Informations de publication
Date de publication:
12 Jan 2023
12 Jan 2023
Historique:
received:
14
12
2022
revised:
01
01
2023
accepted:
10
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
The corneal epithelium is composed of nonkeratinized stratified squamous cells and has a significant turnover rate. Limbal integrity is vital to maintain the clarity and avascularity of the cornea as well as regeneration of the corneal epithelium. Limbal epithelial stem cells (LESCs) are located in the basal epithelial layer of the limbus and preserve this homeostasis. Proper functioning of LESCs is dependent on a specific microenvironment, known as the limbal stem cell niche (LSCN). This structure is made up of various cells, an extracellular matrix (ECM), and signaling molecules. Different etiologies may damage the LSCN, leading to limbal stem cell deficiency (LSCD), which is characterized by conjunctivalization of the cornea. In this review, we first summarize the basics of the LSCN and then focus on current and emerging bioengineering strategies for LSCN restoration to combat LSCD.
Identifiants
pubmed: 36671683
pii: bioengineering10010111
doi: 10.3390/bioengineering10010111
pmc: PMC9855097
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NEI/NIH
ID : R01 EY024349 (ARD)
Organisme : NEI/NIH
ID : UH3 EY031809 (ARD)
Organisme : NEI/NIH
ID : Core Grant for Vision Research EY01792
Organisme : United States Department of Defense
ID : Vision Research Program - Congressionally Directed Medical Research Program VR170180
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