Significance of Pulmonary Endothelial Injury and the Role of Cyclooxygenase-2 and Prostanoid Signaling.
acute respiratory distress
cyclooxygenases
eicosanoids
endothelial barrier dysfunction
lung endothelium
lung infection
lung inflammation
prostanoid receptors
selective cyclooxygenase-2 inhibitors (COXIBs)
traditional non-steroidal anti-inflammatory drugs (tNSAIDs)
Journal
Bioengineering (Basel, Switzerland)
ISSN: 2306-5354
Titre abrégé: Bioengineering (Basel)
Pays: Switzerland
ID NLM: 101676056
Informations de publication
Date de publication:
14 Jan 2023
14 Jan 2023
Historique:
received:
07
11
2022
revised:
11
01
2023
accepted:
13
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
The endothelium plays a key role in the dynamic balance of hemodynamic, humoral and inflammatory processes in the human body. Its central importance and the resulting therapeutic concepts are the subject of ongoing research efforts and form the basis for the treatment of numerous diseases. The pulmonary endothelium is an essential component for the gas exchange in humans. Pulmonary endothelial dysfunction has serious consequences for the oxygenation and the gas exchange in humans with the potential of consecutive multiple organ failure. Therefore, in this review, the dysfunction of the pulmonary endothel due to viral, bacterial, and fungal infections, ventilator-related injury, and aspiration is presented in a medical context. Selected aspects of the interaction of endothelial cells with primarily alveolar macrophages are reviewed in more detail. Elucidation of underlying causes and mechanisms of damage and repair may lead to new therapeutic approaches. Specific emphasis is placed on the processes leading to the induction of cyclooxygenase-2 and downstream prostanoid-based signaling pathways associated with this enzyme.
Identifiants
pubmed: 36671689
pii: bioengineering10010117
doi: 10.3390/bioengineering10010117
pmc: PMC9855370
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Curr Opin Crit Care. 2008 Oct;14(5):580-6
pubmed: 18787453
J Biol Chem. 2020 Dec 25;295(52):18276-18283
pubmed: 33109609
Anesthesiology. 1999 Aug;91(2):486-99
pubmed: 10443613
Infect Immun. 2017 Dec 19;86(1):
pubmed: 29084896
Am J Respir Crit Care Med. 2005 Jun 1;171(11):1260-6
pubmed: 15750045
J Clin Invest. 1995 Jul;96(1):107-16
pubmed: 7615779
J Immunol. 2004 Aug 1;173(3):2031-40
pubmed: 15265938
Mol Microbiol. 2009 Apr;72(1):155-69
pubmed: 19220748
J Immunol. 2020 Aug 15;205(4):1157-1166
pubmed: 32690653
Ann Med. 2005;37(3):154-72
pubmed: 16019714
Hong Kong Med J. 2013 Jun;19 Suppl 4:29-35
pubmed: 23775184
Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L134-43
pubmed: 15778247
Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1;320(3):L377-L392
pubmed: 33296268
Am J Respir Cell Mol Biol. 2010 Dec;43(6):662-73
pubmed: 20081052
J Biol Chem. 2008 May 9;283(19):13437-49
pubmed: 18326860
Am J Pathol. 1995 Mar;146(3):552-79
pubmed: 7887439
Thorax. 2021 Apr;76(4):412-420
pubmed: 33408195
Mol Biol Cell. 2017 Jun 15;28(12):1622-1635
pubmed: 28428256
BMC Pharmacol Toxicol. 2017 Mar 29;18(1):25
pubmed: 28356130
J Clin Invest. 1991 Sep;88(3):864-75
pubmed: 1885774
Am J Respir Crit Care Med. 2002 Sep 1;166(5):657-62
pubmed: 12204861
PLoS Pathog. 2014 Mar 13;10(3):e1003939
pubmed: 24626230
PLoS One. 2012;7(11):e49209
pubmed: 23166614
Sci Rep. 2016 Dec 15;6:39018
pubmed: 27976727
Cell Mol Life Sci. 2014 May;71(10):1927-41
pubmed: 23974244
Redox Biol. 2021 Jan;38:101785
pubmed: 33221570
Circ Res. 2007 Feb 2;100(2):158-73
pubmed: 17272818
Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L710-L721
pubmed: 28663336
J Immunol. 2010 Nov 15;185(10):6265-76
pubmed: 20926798
Cardiovasc Res. 2006 Jun 1;70(3):446-56
pubmed: 16458868
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7594-7
pubmed: 12032328
Br J Pharmacol. 2009 Oct;158(4):1017-33
pubmed: 19845685
Nat Rev Mol Cell Biol. 2004 Apr;5(4):261-70
pubmed: 15071551
PLoS Biol. 2007 Mar;5(3):e64
pubmed: 17311474
Arch Pharm Res. 2001 Oct;24(5):397-401
pubmed: 11693538
Nat Cell Biol. 2009 Nov;11(11):1325-31
pubmed: 19855388
Int J Dev Biol. 2000;44(6):743-8
pubmed: 11061439
J Immunol. 2005 Apr 15;174(8):5033-9
pubmed: 15814734
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13837-42
pubmed: 12368479
Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H1-H10
pubmed: 11123211
Am J Physiol Lung Cell Mol Physiol. 2008 Apr;294(4):L755-63
pubmed: 18245267
Acta Cir Bras. 2021 Oct 25;36(9):e360901
pubmed: 34705944
Front Pharmacol. 2020 Nov 06;11:561674
pubmed: 33312125
Biochem Pharmacol. 2017 Aug 15;138:205-215
pubmed: 28642034
Vascul Pharmacol. 2010 May-Jun;52(5-6):175-81
pubmed: 20060932
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Eur J Pharmacol. 2015 Dec 15;769:333-41
pubmed: 26610718
Infect Immun. 2010 Nov;78(11):4754-62
pubmed: 20713630
J Zhejiang Univ Sci B. 2007 Jan;8(1):60-9
pubmed: 17173364
Curr Opin Microbiol. 2019 Dec;52:100-109
pubmed: 31288097
Anesth Analg. 1993 Oct;77(4):754-60
pubmed: 8214660
Infect Immun. 2007 Jan;75(1):488-96
pubmed: 17101670
EMBO J. 2011 Aug 19;30(20):4157-70
pubmed: 21857650
J Clin Invest. 2010 Jun;120(6):1914-24
pubmed: 20484814
N Engl J Med. 2000 May 4;342(18):1334-49
pubmed: 10793167
Sci Rep. 2021 Jun 16;11(1):12703
pubmed: 34135459
Respir Res. 2017 Jan 18;18(1):20
pubmed: 28100233
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Sci Rep. 2016 Aug 26;6:32109
pubmed: 27562142
Circ Res. 2019 Oct 11;125(9):847-854
pubmed: 31510878
Arch Pathol Lab Med. 2001 Mar;125(3):375-8
pubmed: 11231486
Int J Clin Exp Med. 2015 May 15;8(5):6804-12
pubmed: 26221218
Am J Respir Cell Mol Biol. 2014 Jan;50(1):170-9
pubmed: 23972231
J Microbiol. 2013 Dec;51(6):724-30
pubmed: 24385347
Annu Rev Pharmacol Toxicol. 2001;41:661-90
pubmed: 11264472
Biochem Biophys Res Commun. 2013 Aug 23;438(2):249-56
pubmed: 23850620
Circ Res. 2004 Apr 2;94(6):735-42
pubmed: 14963009
Circ Res. 2004 Jul 23;95(2):196-203
pubmed: 15192021
Acta Physiol (Oxf). 2017 Apr;219(4):728-756
pubmed: 27381367
Biochem Biophys Res Commun. 2009 Nov 20;389(3):531-6
pubmed: 19747898
Front Immunol. 2022 Aug 16;13:968336
pubmed: 36052067
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17597-602
pubmed: 23045674
Circ Res. 2012 Jun 22;111(1):110-30
pubmed: 22723222
Int J Mol Sci. 2014 Oct 28;15(11):19650-61
pubmed: 25353180
Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L785-97
pubmed: 12639843
Cell. 2020 Nov 12;183(4):1043-1057.e15
pubmed: 32970989
Cell. 2011 Sep 16;146(6):980-91
pubmed: 21925319
Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep;69(2-3):157-62
pubmed: 12895598
J Cell Physiol. 2003 Oct;197(1):86-93
pubmed: 12942544
Mucosal Immunol. 2010 May;3(3):291-300
pubmed: 20404812
J Biol Chem. 1999 May 28;274(22):15719-24
pubmed: 10336471
Biomed Pharmacother. 2022 Nov;155:113721
pubmed: 36152413
Sci Transl Med. 2010 Mar 17;2(23):23ra19
pubmed: 20375003
Int J Mol Med. 2018 May;41(5):2505-2516
pubmed: 29436612
Front Immunol. 2020 Sep 02;11:2167
pubmed: 33013911
Am J Pathol. 2002 Dec;161(6):2153-67
pubmed: 12466131
Annu Rev Biochem. 2000;69:145-82
pubmed: 10966456
Microb Pathog. 2021 Jan;150:104689
pubmed: 33307121
Mod Pathol. 2013 Mar;26(3):357-69
pubmed: 23174938
J Mol Biol. 1998 Feb 20;276(2):325-30
pubmed: 9512705
Thorax. 2016 May;71(5):462-73
pubmed: 26968969
Am J Clin Pathol. 2007 Mar;127(3):349-55
pubmed: 17276936
Infect Immun. 2008 Aug;76(8):3429-38
pubmed: 18490455
Eur J Immunol. 2013 Mar;43(3):679-92
pubmed: 23280543
Microvasc Res. 2014 Mar;92:50-55
pubmed: 24370952
mBio. 2016 Oct 25;7(5):
pubmed: 27795403
Am J Respir Cell Mol Biol. 2012 Mar;46(3):331-41
pubmed: 21997484
Infect Immun. 2010 Jul;78(7):3007-18
pubmed: 20439478
PLoS Pathog. 2016 Jul 14;12(7):e1005738
pubmed: 27416066
Thromb Haemost. 2007 Aug;98(2):319-26
pubmed: 17721613
Annu Rev Pharmacol Toxicol. 2009;49:265-90
pubmed: 18851701
Infect Dis Ther. 2021 Mar;10(Suppl 1):5-16
pubmed: 33660239
Int J Inflam. 2014;2014:972645
pubmed: 24579056
Shock. 2021 Feb 1;55(2):236-243
pubmed: 32590697
FASEB J. 2017 Sep;31(9):4187-4202
pubmed: 28572443
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Am J Physiol. 1997 Jul;273(1 Pt 1):L217-26
pubmed: 9252559
Nature. 2020 Dec;588(7839):688-692
pubmed: 33268895
Int J Mol Sci. 2019 Apr 10;20(7):
pubmed: 30974834
J Pharmacol Exp Ther. 2005 Oct;315(1):1-7
pubmed: 15879007
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20009-14
pubmed: 19060214
J Immunol. 2005 Jun 1;174(11):7359-67
pubmed: 15905583
Respir Care. 2014 Sep;59(9):1422-32
pubmed: 25053831
Mol Interv. 2006 Aug;6(4):199-207
pubmed: 16960142
Eur J Immunol. 2015 Jun;45(6):1680-95
pubmed: 25763996
J Infect Dis. 2004 Apr 15;189(8):1411-8
pubmed: 15073678
Int J Biochem Cell Biol. 2004 Jul;36(7):1187-205
pubmed: 15109566
Pediatr Res. 2003 May;53(5):731-6
pubmed: 12621123
J Infect Dis. 2002 May 15;185(10):1483-9
pubmed: 11992285
Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1059-68
pubmed: 16387754
BMB Rep. 2009 Sep 30;42(9):552-60
pubmed: 19788855
Microcirculation. 2010 Jul;17(5):394-406
pubmed: 20618696
Front Microbiol. 2017 Jun 23;8:1041
pubmed: 28690590
Eur J Anaesthesiol. 2006 Dec;23(12):1041-8
pubmed: 16836770
Sci Rep. 2020 Jul 7;10(1):11186
pubmed: 32636414
J Infect Dis. 1999 Feb;179(2):295-302
pubmed: 9878011
J Infect Dis. 2009 Apr 1;199(7):1087-96
pubmed: 19222370
J Cell Physiol. 2018 Aug;233(8):5736-5746
pubmed: 29168172
Med Res Rev. 2001 May;21(3):185-210
pubmed: 11301410
Tissue Barriers. 2015 Apr 03;3(1-2):e974448
pubmed: 25838980
J Clin Invest. 2001 Sep;108(5):689-701
pubmed: 11544274
Am J Respir Cell Mol Biol. 2014 Oct;51(4):502-15
pubmed: 24749674
Microorganisms. 2020 May 30;8(6):
pubmed: 32486193
Res Exp Med (Berl). 1994;194(1):25-33
pubmed: 8202636
J Immunol. 2017 Sep 15;199(6):2140-2148
pubmed: 28784844
N Engl J Med. 2005 Oct 20;353(16):1685-93
pubmed: 16236739
Am J Respir Cell Mol Biol. 2005 Oct;33(4):319-27
pubmed: 16172252
J Immunol. 2008 Jan 1;180(1):541-9
pubmed: 18097056
Expert Opin Pharmacother. 2013 Jun;14(8):1077-86
pubmed: 23517091
Mycopathologia. 2005 Feb;159(2):181-8
pubmed: 15770441
Br J Pharmacol. 1995 Dec;116(7):3035-41
pubmed: 8680740
Infect Immun. 2014 Sep;82(9):3567-79
pubmed: 24914216
J Biol Chem. 2002 Nov 29;277(48):45838-46
pubmed: 12237321
J Biol Chem. 2016 Mar 11;291(11):5484-5499
pubmed: 26719334
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L787-L801
pubmed: 34405715
J Lipid Res. 2009 Apr;50 Suppl:S423-8
pubmed: 19095631
J Clin Invest. 2014 Jan;124(1):237-50
pubmed: 24355926
Mediators Inflamm. 2013;2013:791231
pubmed: 23690670
Cell Microbiol. 2009 Jan;11(1):170-82
pubmed: 19016788
Cell Mol Life Sci. 2015 May;72(10):1863-79
pubmed: 25666877
Nat Microbiol. 2016 Nov 14;2:16211
pubmed: 27841851
Gene. 2019 Apr 15;692:176-184
pubmed: 30660713
Adv Appl Microbiol. 2014;87:1-41
pubmed: 24581388
Trends Cell Biol. 2009 Jan;19(1):8-15
pubmed: 19010680
Circ Res. 2007 Feb 2;100(2):174-90
pubmed: 17272819
Cold Spring Harb Perspect Med. 2014 Nov 10;5(7):a019661
pubmed: 25384769
Lancet Infect Dis. 2018 Nov;18(11):1191-1210
pubmed: 30243584
Ultrastruct Pathol. 2011 Aug;35(4):155-61
pubmed: 21657817
Respir Physiol Neurobiol. 2011 Apr 30;176(1-2):39-49
pubmed: 21244858
Blood. 2004 Mar 15;103(6):2143-9
pubmed: 14630829
Viruses. 2019 Mar 19;11(3):
pubmed: 30893947
J Infect Dis. 2002 Nov 1;186(9):1199-206
pubmed: 12402188
J Biol Chem. 2012 Jul 20;287(30):25407-18
pubmed: 22637478
Nature. 2020 Oct;586(7831):785-789
pubmed: 33057196
Cancer Prev Res (Phila). 2009 Apr;2(4):288-90
pubmed: 19336721
Physiol Rev. 2006 Jan;86(1):279-367
pubmed: 16371600
Viral Immunol. 2010 Feb;23(1):43-8
pubmed: 20121401
Medicine (Baltimore). 2000 Jul;79(4):250-60
pubmed: 10941354
J Cell Physiol. 2021 Apr;236(4):2893-2905
pubmed: 32959895
Int J Mol Med. 2012 Jun;29(6):1025-30
pubmed: 22446935
Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:67-73
pubmed: 23000418
Biochem Pharmacol. 2020 Dec;182:114277
pubmed: 33038299
J Intensive Care Med. 2007 Mar-Apr;22(2):63-72
pubmed: 17456726
Eur J Clin Pharmacol. 2020 Nov;76(11):1501-1504
pubmed: 32583353
Int Immunol. 2005 Jan;17(1):1-14
pubmed: 15585605
Vascul Pharmacol. 2008 Oct-Dec;49(4-6):119-33
pubmed: 18722553
Int J Artif Organs. 2011 Sep;34(9):799-810
pubmed: 22094559
J Immunol. 2017 Aug 9;:
pubmed: 28794232
Chem Rev. 2011 Oct 12;111(10):6209-30
pubmed: 21819041
Nat Commun. 2018 Oct 15;9(1):4260
pubmed: 30323213
Chest. 2018 Aug;154(2):317-325
pubmed: 29555594
J Cereb Blood Flow Metab. 2013 Jan;33(1):146-56
pubmed: 23093067
Semin Immunopathol. 2012 Jan;34(1):73-91
pubmed: 21805322
Physiol Rev. 1999 Oct;79(4):1193-226
pubmed: 10508233
Clin Infect Dis. 2007 Feb 15;44(4):531-40
pubmed: 17243056
Kidney Int. 1998 Dec;54(6):1899-908
pubmed: 9853255
PLoS Pathog. 2021 Mar 18;17(3):e1009358
pubmed: 33735255
Eur Respir J. 2012 Dec;40(6):1458-67
pubmed: 22441740
Infect Immun. 2000 Jun;68(6):3485-90
pubmed: 10816502
Am J Respir Cell Mol Biol. 1999 Mar;20(3):465-73
pubmed: 10030845
Front Immunol. 2017 Jul 21;8:842
pubmed: 28785264
Antioxidants (Basel). 2020 Jan 25;9(2):
pubmed: 31991739
Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L797-805
pubmed: 16603593
Trends Immunol. 2009 Dec;30(12):574-84
pubmed: 19864182
Oncogene. 1999 Dec 20;18(55):7908-16
pubmed: 10630643
Am J Respir Cell Mol Biol. 2012 Oct;47(4):445-53
pubmed: 22582175
Infect Immun. 2005 Feb;73(2):778-83
pubmed: 15664916
Thromb Haemost. 2005 Aug;94(2):295-303
pubmed: 16113818
Pharmacol Res. 2006 Apr;53(4):372-9
pubmed: 16504535
Br J Pharmacol. 2020 Nov;177(21):4899-4920
pubmed: 32700336
Microvasc Res. 2011 Mar;81(2):189-97
pubmed: 21146549
Pharmacol Ther. 2021 Jan;217:107624
pubmed: 32640277
Int J Mol Sci. 2020 Nov 20;21(22):
pubmed: 33233715
Eur Respir J. 2019 Mar 28;53(3):
pubmed: 30635296
Exp Cell Res. 2008 Nov 15;314(19):3466-77
pubmed: 18824167
Am J Respir Cell Mol Biol. 2012 Sep;47(3):387-94
pubmed: 22556158
Crit Care. 2010;14(1):R1
pubmed: 20055989
Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L883-93
pubmed: 23585225
PLoS One. 2010 May 18;5(5):e10690
pubmed: 20502528
Eukaryot Cell. 2010 Oct;9(10):1432-40
pubmed: 20675576
Int J Infect Dis. 2020 Dec;101:29-32
pubmed: 33007455
Mediators Inflamm. 2013;2013:950981
pubmed: 23818746
J Clin Invest. 2006 Dec;116(12):3211-9
pubmed: 17143330
Anesthesiology. 1992 Oct;77(4):772-8
pubmed: 1416175
Curr Med Chem. 2006;13(19):2241-51
pubmed: 16918352
Intensive Care Med Exp. 2018 Jul 5;6(1):15
pubmed: 29978355
Intensive Care Med. 2006 Jan;32(1):24-33
pubmed: 16231069