Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.
DNA methylation
biological age
cerebral small vessel disease
epigenetic clock
epigenetics
white matter hyperintensities
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
24 Dec 2022
24 Dec 2022
Historique:
received:
18
11
2022
revised:
19
12
2022
accepted:
22
12
2022
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured using a semi-automated method. B-age was calculated using two widely used methods: the Hannum and Horvath formulas. We used multiple linear regression models to interrogate the role of B-age on WMH volume after adjusting for chronological age (C-age) and other covariables. Average C-age of the sample was 68.4 (±11.8) and we observed a relatively high median WMH volume (median = 8.8 cm
Identifiants
pubmed: 36671726
pii: biology12010033
doi: 10.3390/biology12010033
pmc: PMC9855342
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI051737
Organisme : Instituto de Salud Carlos III
ID : PI10/02064
Organisme : Instituto de Salud Carlos III
ID : PI12/01238
Organisme : Instituto de Salud Carlos III
ID : PI15/00451
Organisme : Instituto de Salud Carlos III
ID : PI18/00022
Organisme : Instituto de Salud Carlos III
ID : PI21/00593
Organisme : Red INVICTUS
ID : RD16/0019/0002
Organisme : Red INVICTUS
ID : RD21/0006/0021
Organisme : Instituto de Salud Carlos III
ID : JR18/00004
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