The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in
contralateral breast cancer
exome sequencing
genomics
hereditary breast cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Jan 2023
08 Jan 2023
Historique:
received:
13
12
2022
revised:
27
12
2022
accepted:
03
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
Contralateral breast cancer (CBC) is associated with younger age at first diagnosis, family history and pathogenic germline variants (PGVs) in genes such as In this nested case-control study, participants negative for The PGVs burden in Group 1 was significantly higher in CBC than in UBC ( In younger
Sections du résumé
BACKGROUND
BACKGROUND
Contralateral breast cancer (CBC) is associated with younger age at first diagnosis, family history and pathogenic germline variants (PGVs) in genes such as
METHODS
METHODS
In this nested case-control study, participants negative for
RESULTS
RESULTS
The PGVs burden in Group 1 was significantly higher in CBC than in UBC (
CONCLUSION
CONCLUSIONS
In younger
Identifiants
pubmed: 36672364
pii: cancers15020415
doi: 10.3390/cancers15020415
pmc: PMC9856968
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Union Seventh Framework Program
ID : 2007e2013
Organisme : US National Institute of Health
ID : R01CA097397, R01CA114236, R01CA129639
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIHR Cambridge Biomedical Research Centre
ID : BRC-1215-20014
Organisme : MSK Cancer Center Support Grant
ID : P30CA008748
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