Surgical Strategies for Recurrent Hepatocellular Carcinoma after Resection: A Review of Current Evidence.

hepatocellular carcinoma liver resection liver transplant recurrent hepatocellular carcinoma salvage liver transplant surgical management

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
13 Jan 2023
Historique:
received: 02 12 2022
revised: 07 01 2023
accepted: 10 01 2023
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 22 1 2023
Statut: epublish

Résumé

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and both liver resection and liver transplantation are considered potentially curative options. However, high recurrence rates affect the prognosis depending both on the primary HCC pathology characteristics or on the type and time of the relapse. While great attention has been usually posted on treatment algorithms for the first HCC, treatment algorithms for recurrent HCC (rHCC) are lacking. In these cases, surgery still represents a curative option with both redo hepatectomy and/or salvage liver transplantation, which are considered valid treatments in selected patients. In the current era of personalised medicine with promises of new systemic-targeted immuno-chemotherapies, we wished to perform a narrative review of the literature on the role of surgical strategies for rHCC.

Identifiants

pubmed: 36672457
pii: cancers15020508
doi: 10.3390/cancers15020508
pmc: PMC9856445
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Flavio Milana (F)

Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy.
Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.

Michela Anna Polidoro (MA)

Hepatobiliary Immunopathology Laboratory, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.

Simone Famularo (S)

Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy.
Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.

Ana Lleo (A)

Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy.
Department of Internal Medicine, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.

Renzo Boldorini (R)

Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, NO, Italy.
Department of Pathology, University Maggiore Hospital, 28100 Novara, NO, Italy.

Matteo Donadon (M)

Hepatobiliary Immunopathology Laboratory, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.
Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, NO, Italy.
Department of General Surgery, University Maggiore Hospital, 28100 Novara, NO, Italy.

Guido Torzilli (G)

Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy.
Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.

Classifications MeSH