A High MCM6 Proliferative Index in Atypical Meningioma Is Associated with Shorter Progression Free and Overall Survivals.
Ki-67
MCM6
PTEN
atypical meningioma
meningioma
proliferation
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Jan 2023
16 Jan 2023
Historique:
received:
15
12
2022
revised:
07
01
2023
accepted:
12
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
The aim of this study was to evaluate the prognostic value of MCM6, in comparison with Ki-67, in two series of grade 1 and 2 meningiomas, and to evaluate its correlation with methylation classes. The first cohort included 100 benign (grade 1, World Health Organization 2021) meningiomas, and the second 69 atypical meningiomas (grade 2). Immunohistochemical Ki-67 and MCM6 labeling indices (LI) were evaluated independently by two observers. Among the atypical meningiomas, 33 cases were also studied by genome-wide DNA methylation. In grade 2 meningiomas, but not grade 1, both Ki-67 and MCM6 LIs were correlated with PFS (
Identifiants
pubmed: 36672484
pii: cancers15020535
doi: 10.3390/cancers15020535
pmc: PMC9857276
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : INSERM U1256 NGERE, CHRU Nancy
ID : NA
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