Spinal Metastasis in a Patient with Supratentorial Glioblastoma with Primitive Neuronal Component: A Case Report with Clinical and Molecular Evaluation.
ARID1A
NF1
NOTCH3
glioblastoma
metastasis
mutation
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
04 Jan 2023
04 Jan 2023
Historique:
received:
15
10
2022
revised:
27
12
2022
accepted:
31
12
2022
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
Glioblastoma (GBM) is regarded as an aggressive brain tumor that rarely develops extracranial metastases. Despite well-investigated molecular alterations in GBM, there is a limited understanding of these associated with the metastatic potential. We herein present a case report of a 43-year-old woman with frontal GBM with primitive neuronal component who underwent gross total resection followed by chemoradiation. Five months after surgery, the patient was diagnosed with an intraspinal GBM metastasis. Next-generation sequencing analysis of both the primary and metastatic GBM tissues was performed using the Illumina TruSight Tumor 170 assay. The number of single nucleotide variants observed in the metastatic sample was more than two times higher. Mutations in
Identifiants
pubmed: 36672991
pii: diagnostics13020181
doi: 10.3390/diagnostics13020181
pmc: PMC9858260
pii:
doi:
Types de publication
Case Reports
Langues
eng
Subventions
Organisme : Masaryk University
ID : MUNI/A/1645/2020
Organisme : Masaryk University
ID : MUNI/A/1408/2021
Organisme : Ministry of Education, Youth and Sports, Czech Republic
ID : INTER-EXCELLENCE, No. LTC20027
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