Contrast Enhanced EUS for Predicting Solid Pancreatic Neuroendocrine Tumor Grade and Aggressiveness.

CE-EUS CH-EUS EUS NET PNET aggressiveness grading

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
09 Jan 2023
Historique:
received: 30 11 2022
revised: 29 12 2022
accepted: 29 12 2022
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 22 1 2023
Statut: epublish

Résumé

Pancreatic neuroendocrine tumor (PNET) behavior assessment is a daily challenge for physicians. Modern PNET management varies from a watch-and-wait strategy to surgery depending on tumor aggressiveness. Therefore, the aggressiveness definition plays a pivotal role in the PNET work-up. The aggressiveness of PNETs is mainly based on the dimensions and histological grading, with sometimes a lack of specificity and sensibility. In the last twenty years, EUS has become a cornerstone in the diagnostic phase of PNET management for its high diagnostic yield and the possibility of obtaining a histological specimen. The number of EUS applications in the PNET work-up has been rapidly increasing with new and powerful possibilities. The application of contrast has led to an important step in PNET detection; in recent years, it has been gaining interesting applications in aggressiveness assessment. In this review, we underline the latest experiences and opportunities in the behavior assessment of PNETs using contact-enhanced EUS and contested enhanced harmonic EUS with a particular focus on the future application and possibility that these techniques could provide.

Identifiants

pubmed: 36673049
pii: diagnostics13020239
doi: 10.3390/diagnostics13020239
pmc: PMC9857765
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Gianluca Franchellucci (G)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, 21053 Castellanza, Italy.
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy.

Marta Andreozzi (M)

Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.
Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, 80131 Naples, Italy.

Silvia Carrara (S)

Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.

Luca De Luca (L)

Endoscopic Unit, ASST Santi Paolo e Carlo, 20142 Milan, Italy.

Francesco Auriemma (F)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, 21053 Castellanza, Italy.

Danilo Paduano (D)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, 21053 Castellanza, Italy.

Federica Calabrese (F)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, 21053 Castellanza, Italy.

Antonio Facciorusso (A)

Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.

Valeria Poletti (V)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, 21053 Castellanza, Italy.
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy.

Alessandro Zerbi (A)

Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy.
Pancreatic Surgery Unit, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.

Andrea Gerardo Lania (AG)

Endocrinology, Diabetology and Medical Andrology Unit, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.

Alexia Francesca Bertuzzi (AF)

Medical Oncology and Hematology Unit, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.

Paola Spaggiari (P)

Department of Pathology, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.

Vittorio Pedicini (V)

Department of Interventional Radiology, Humanitas University, Humanitas Research Hospital IRCCS, 20089 Rozzano, Italy.

Marcello Rodari (M)

Department of Nuclear Medicine, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Italy.

Pietro Fusaroli (P)

Gastroenterology Unit, Hospital of Imola, University of Bologna, 40126 Imola, Italy.

Andrea Lisotti (A)

Gastroenterology Unit, Hospital of Imola, University of Bologna, 40126 Imola, Italy.

Andrew Ofosu (A)

Division of Gastroenterology and Hepatology, University of Cincinnati, Cincinnati, OH 45221, USA.

Alessandro Repici (A)

Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy.
Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.

Benedetto Mangiavillano (B)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, 21053 Castellanza, Italy.
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy.

Classifications MeSH