Role of Hsp70 in Post-Translational Protein Targeting: Tail-Anchored Membrane Proteins and Beyond.
GET pathway
Hsp70
J-domain protein
endoplasmic reticulum
membrane protein
mitochondria
molecular chaperone
protein targeting
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Jan 2023
06 Jan 2023
Historique:
received:
29
11
2022
revised:
02
01
2023
accepted:
04
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
The Hsp70 family of molecular chaperones acts as a central 'hub' in the cell that interacts with numerous newly synthesized proteins to assist in their biogenesis. Apart from its central and well-established role in facilitating protein folding, Hsp70s also act as key decision points in the cellular chaperone network that direct client proteins to distinct biogenesis and quality control pathways. In this paper, we review accumulating data that illustrate a new branch in the Hsp70 network: the post-translational targeting of nascent membrane and organellar proteins to diverse cellular organelles. Work in multiple pathways suggests that Hsp70, via its ability to interact with components of protein targeting and translocation machineries, can initiate elaborate substrate relays in a sophisticated cascade of chaperones, cochaperones, and receptor proteins, and thus provide a mechanism to safeguard and deliver nascent membrane proteins to the correct cellular membrane. We discuss the mechanistic principles gleaned from better-studied Hsp70-dependent targeting pathways and outline the observations and outstanding questions in less well-studied systems.
Identifiants
pubmed: 36674686
pii: ijms24021170
doi: 10.3390/ijms24021170
pmc: PMC9866221
pii:
doi:
Substances chimiques
Membrane Proteins
0
HSP70 Heat-Shock Proteins
0
Molecular Chaperones
0
Carrier Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM135321
Pays : United States
Références
Mol Cell Biol. 1996 Aug;16(8):4378-86
pubmed: 8754838
Protein Sci. 2017 Sep;26(9):1838-1851
pubmed: 28685898
Nature. 2009 Sep 17;461(7262):361-6
pubmed: 19675567
J Biol Chem. 2008 Apr 4;283(14):8877-84
pubmed: 18218635
Nature. 1991 Feb 28;349(6312):806-8
pubmed: 2000150
J Cell Biol. 2018 Sep 3;217(9):3091-3108
pubmed: 29930205
J Mol Biol. 2001 Feb 16;306(2):137-43
pubmed: 11237589
Cell. 2005 Nov 4;123(3):507-19
pubmed: 16269340
Cold Spring Harb Perspect Biol. 2019 Sep 3;11(9):
pubmed: 30745292
Nat Struct Mol Biol. 2008 Dec;15(12):1255-62
pubmed: 19011634
Nature. 2022 Feb;602(7897):487-495
pubmed: 34942634
Cell. 2008 Jun 13;133(6):1068-79
pubmed: 18555782
Nature. 2016 Nov 30;540(7631):134-138
pubmed: 27905431
Annu Rev Biophys. 2014;43:381-408
pubmed: 24895856
Cell. 1995 May 19;81(4):561-70
pubmed: 7758110
J Biol Chem. 2019 Feb 8;294(6):2085-2097
pubmed: 30455352
J Biol Chem. 2021 Jan-Jun;296:100546
pubmed: 33741343
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12860-5
pubmed: 9789005
J Biol Chem. 2003 Mar 7;278(10):7897-901
pubmed: 12456682
Nature. 2010 Aug 26;466(7310):1120-4
pubmed: 20676083
Cell. 2017 Aug 10;170(4):693-700.e7
pubmed: 28802041
Traffic. 2001 Apr;2(4):252-60
pubmed: 11285135
Elife. 2022 Jul 25;11:
pubmed: 35876647
Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):106-11
pubmed: 25535373
Nat Commun. 2021 May 14;12(1):2843
pubmed: 33990585
Trends Biochem Sci. 2016 Jan;41(1):62-76
pubmed: 26422689
Cell. 2008 Aug 22;134(4):634-45
pubmed: 18724936
FEBS J. 2016 Sep;283(18):3338-52
pubmed: 27412066
Nat Rev Mol Cell Biol. 2010 Aug;11(8):579-92
pubmed: 20651708
Nat Struct Mol Biol. 2022 Aug;29(8):820-830
pubmed: 35851188
Mol Cell. 2010 Oct 8;40(1):159-71
pubmed: 20850366
Nature. 2015 Aug 13;524(7564):247-51
pubmed: 26245380
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4207-12
pubmed: 8633042
J Biol Chem. 2012 Mar 9;287(11):8310-7
pubmed: 22262836
Science. 2018 Sep 14;361(6407):1118-1122
pubmed: 30213914
Cell Metab. 2021 Dec 7;33(12):2464-2483.e18
pubmed: 34800366
Mol Cell. 2005 Nov 23;20(4):525-38
pubmed: 16307917
Cell Mol Life Sci. 2005 Mar;62(6):670-84
pubmed: 15770419
Cell Rep. 2017 Jun 27;19(13):2836-2852
pubmed: 28658629
Cell. 2000 Mar 3;100(5):551-60
pubmed: 10721992
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21131-6
pubmed: 19948960
J Biol Chem. 2014 May 9;289(19):13155-67
pubmed: 24671421
Front Mol Biosci. 2017 Dec 07;4:83
pubmed: 29270408
Science. 2017 May 26;356(6340):
pubmed: 28495876
Nature. 1988 Apr 28;332(6167):800-5
pubmed: 3282178
Nat Chem Biol. 2010 Dec;6(12):914-20
pubmed: 20953191
Cell Mol Immunol. 2020 Sep;17(9):998-1000
pubmed: 32728199
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4929-35
pubmed: 25368153
Nat Struct Mol Biol. 2012 Dec;19(12):1347-55
pubmed: 23160352
Annu Rev Biochem. 2013;82:323-55
pubmed: 23746257
J Biol Chem. 2003 Mar 7;278(10):8219-23
pubmed: 12514182
Nature. 2019 Feb;566(7742):136-139
pubmed: 30644436
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1327-32
pubmed: 23297211
RSC Adv. 2021 Oct 1;11(51):32476-32493
pubmed: 35495482
Nat Struct Mol Biol. 2010 Jun;17(6):696-702
pubmed: 20424608
Cell Discov. 2020 Sep 29;6:67
pubmed: 33083003
Curr Opin Cell Biol. 2022 Apr;75:102071
pubmed: 35306313
J Mol Biol. 2009 May 22;388(5):1043-58
pubmed: 19358854
Cell. 1992 Dec 24;71(7):1143-55
pubmed: 1473150
J Mol Biol. 2015 Apr 10;427(7):1575-88
pubmed: 25683596
Nature. 2016 Nov 17;539(7629):448-451
pubmed: 27783598
Cell Rep. 2019 Jan 2;26(1):37-44.e7
pubmed: 30605684
Annu Rev Cell Dev Biol. 2017 Oct 6;33:417-438
pubmed: 28992441
J Biol Chem. 2011 Sep 30;286(39):34325-34
pubmed: 21832041
Nat Struct Mol Biol. 2014 May;21(5):437-42
pubmed: 24727835
Methods Mol Biol. 2018;1709:179-188
pubmed: 29177659
Trends Cell Biol. 2019 Jul;29(7):534-548
pubmed: 31030976
Science. 2018 Jan 26;359(6374):470-473
pubmed: 29242231
Cell. 1998 Jul 10;94(1):73-82
pubmed: 9674429
Science. 2013 Mar 1;339(6123):1080-3
pubmed: 23393091
Cell Stress Chaperones. 2019 Jan;24(1):7-15
pubmed: 30478692
Biochem J. 2001 Jul 1;357(Pt 1):157-65
pubmed: 11415446
J Biol Chem. 2008 Feb 15;283(7):3799-807
pubmed: 18063580
Nat Struct Mol Biol. 2019 Dec;26(12):1158-1166
pubmed: 31740857
J Biol Chem. 2021 Jan-Jun;296:100441
pubmed: 33610544
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7666-71
pubmed: 23610396
Structure. 2006 Jul;14(7):1157-65
pubmed: 16843897
J Mol Biol. 2006 Feb 24;356(3):802-11
pubmed: 16403523
PLoS One. 2009 Nov 30;4(11):e8061
pubmed: 19956640
J Biol Chem. 2015 Dec 11;290(50):30006-17
pubmed: 26451041
J Biol Chem. 2017 May 12;292(19):8007-8018
pubmed: 28286332
J Cell Biol. 2012 Aug 6;198(3):387-404
pubmed: 22869599
Methods Enzymol. 1983;96:682-91
pubmed: 6197610
Annu Rev Cell Biol. 1994;10:87-119
pubmed: 7888184
Science. 2009 Mar 27;323(5922):1693-7
pubmed: 19325107
J Biol Chem. 2010 Mar 26;285(13):9962-9970
pubmed: 20106980
Cell Rep. 2018 Nov 20;25(8):2036-2043.e5
pubmed: 30463002
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8585-E8594
pubmed: 28973888
Science. 2015 Mar 6;347(6226):1152-5
pubmed: 25745174
Nat Commun. 2020 Jan 17;11(1):365
pubmed: 31953415
Trends Cell Biol. 2023 Jan;33(1):30-47
pubmed: 35729039
Nat Rev Mol Cell Biol. 2019 Nov;20(11):665-680
pubmed: 31253954
Nat Commun. 2014 Nov 19;5:5484
pubmed: 25407331
Chem Rev. 2006 May;106(5):1917-30
pubmed: 16683761
Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):
pubmed: 34625496
Cell Rep. 2021 Apr 6;35(1):108936
pubmed: 33826901
Nat Struct Mol Biol. 2006 Jul;13(7):589-93
pubmed: 16767096
J Phys Chem B. 2022 Sep 15;126(36):6780-6791
pubmed: 36040440
Curr Opin Struct Biol. 2012 Apr;22(2):217-24
pubmed: 22444563
Annu Rev Biochem. 2017 Jun 20;86:21-26
pubmed: 28441058
Cell. 2007 Mar 23;128(6):1147-59
pubmed: 17382883
Science. 2017 Jan 20;355(6322):298-302
pubmed: 28104892
J Cell Biol. 2000 Oct 2;151(1):167-78
pubmed: 11018062
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4794-800
pubmed: 27482090
Elife. 2016 Dec 07;5:
pubmed: 27925580
Science. 2018 Feb 9;359(6376):689-692
pubmed: 29348368
Nature. 2022 Jan;601(7893):460-464
pubmed: 34937942
Cell. 2005 Jun 3;121(5):739-48
pubmed: 15935760
Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2200158119
pubmed: 35733257
EMBO J. 2018 Aug 15;37(16):
pubmed: 29973361
Mol Cell Biol. 2013 Oct;33(20):4083-94
pubmed: 23959800
J Mol Biol. 2003 Apr 25;328(2):495-504
pubmed: 12691756
Mol Biol Cell. 2007 Sep;18(9):3414-28
pubmed: 17596514
Traffic. 2021 Sep;22(9):306-318
pubmed: 34288289
J Biol Chem. 2009 Aug 28;284(35):23852-9
pubmed: 19581297
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14849-54
pubmed: 19706470
Cell. 2000 Apr 14;101(2):199-210
pubmed: 10786835
J Cell Biol. 1994 Aug;126(4):935-43
pubmed: 8051213
Cell. 2003 Jan 10;112(1):41-50
pubmed: 12526792
Cell. 1984 Aug;38(1):5-8
pubmed: 6088076
Annu Rev Biochem. 2017 Jun 20;86:685-714
pubmed: 28301740
J Biol Chem. 1997 Aug 15;272(33):20730-5
pubmed: 9252394
Nat Rev Mol Cell Biol. 2011 Nov 16;12(12):787-98
pubmed: 22086371
Biochim Biophys Acta. 2015 Aug;1853(8):1850-9
pubmed: 25958336
Cell. 2013 Feb 28;152(5):1134-45
pubmed: 23452858
FEBS Lett. 2020 Sep;594(17):2770-2781
pubmed: 32446288
Nat Commun. 2021 Feb 4;12(1):782
pubmed: 33542241
Annu Rev Cell Dev Biol. 2017 Oct 6;33:369-390
pubmed: 28564553
Int J Mol Sci. 2021 Dec 28;23(1):
pubmed: 35008707
J Cell Biol. 2018 Apr 2;217(4):1369-1382
pubmed: 29382700
Trends Biochem Sci. 2003 Dec;28(12):655-62
pubmed: 14659697
J Biol Chem. 2009 Nov 13;284(46):31635-46
pubmed: 19767391
Elife. 2017 Jul 14;6:
pubmed: 28708484
Annu Rev Biochem. 2013;82:693-721
pubmed: 23414305
Nature. 1988 Apr 28;332(6167):805-10
pubmed: 3282179
Nature. 2019 Nov;575(7782):395-401
pubmed: 31600774
Science. 2020 Dec 4;370(6521):
pubmed: 33060197
Trends Cell Biol. 1993 Mar;3(3):72-5
pubmed: 14731773