Does the Composition of Gut Microbiota Affect Hypertension? Molecular Mechanisms Involved in Increasing Blood Pressure.
gut microbiota
hypertension
increased blood pressure
microbiome
probiotics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Jan 2023
10 Jan 2023
Historique:
received:
04
12
2022
revised:
29
12
2022
accepted:
09
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
Arterial hypertension is a chronic disease which is very prevalent contemporarily. The aim of this review was to investigate the impact of gut microbiota on the development and potential treatment of hypertension, taking into consideration underlying molecular mechanisms. The bacteria present in the intestines have the ability to secrete different metabolites, which might play a significant role in the regulation of blood pressure. The most important include short-chain fatty acids (SCFAs), vasoactive hormones, trimethylamine (TMA) and trimethylamine N-oxide (TMAO) and uremic toxins, such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS). Their action in regulating blood pressure is mainly based on their pro- or anti-inflammatory function. The use of specifically formulated probiotics to modify the composition of gut microbiota might be a beneficial way of supportive treatment of hypertension; however, further research on this topic is needed to choose the species of bacteria that could induce the hypotensive pattern.
Identifiants
pubmed: 36674891
pii: ijms24021377
doi: 10.3390/ijms24021377
pmc: PMC9863380
pii:
doi:
Substances chimiques
Antihypertensive Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Nature. 2017 Nov 30;551(7682):585-589
pubmed: 29143823
Hypertension. 2019 Oct;74(4):1005-1013
pubmed: 31352822
Clin Cardiol. 2020 Feb;43(2):99-107
pubmed: 31825114
Gastroenterology. 2012 Aug;143(2):e7-8
pubmed: 22727855
Toxins (Basel). 2020 Jan 19;12(1):
pubmed: 31963891
Biochem Pharmacol. 2011 Dec 15;82(12):1891-900
pubmed: 21930116
J Cardiovasc Pharmacol. 2014 May;63(5):466-76
pubmed: 24805148
J Transl Med. 2022 Oct 15;20(1):470
pubmed: 36243862
Clin Res Hepatol Gastroenterol. 2018 Apr;42(2):110-117
pubmed: 29102544
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2247-52
pubmed: 24390544
Am J Hypertens. 2020 Oct 21;33(10):890-901
pubmed: 32614942
Nutrients. 2020 Sep 29;12(10):
pubmed: 33003455
Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F439-44
pubmed: 23761671
Toxins (Basel). 2021 Mar 31;13(4):
pubmed: 33807343
Mol Nutr Food Res. 2016 May;60(5):981-91
pubmed: 26790841
J Clin Endocrinol Metab. 2008 Oct;93(10):3671-89
pubmed: 18664543
Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1307-13
pubmed: 24675659
FASEB J. 2000 Dec;14(15):2380-2
pubmed: 11024006
Hypertension. 2015 Jun;65(6):1331-40
pubmed: 25870193
Physiol Genomics. 2015 Jun;47(6):187-97
pubmed: 25829393
Cell Mol Life Sci. 2019 Feb;76(3):473-493
pubmed: 30317530
Clin Sci (Lond). 2014 Jul;127(1):33-45
pubmed: 24410749
Toxins (Basel). 2020 Sep 11;12(9):
pubmed: 32932981
Am J Clin Nutr. 2003 Feb;77(2):326-30
pubmed: 12540390
J Vet Intern Med. 2019 Mar;33(2):363-382
pubmed: 30806496
Microbiome. 2017 Feb 1;5(1):14
pubmed: 28143587
Nutrients. 2018 Aug 23;10(9):
pubmed: 30142973
Curr Opin Nephrol Hypertens. 2017 Jan;26(1):1-8
pubmed: 27798455
Kardiol Pol. 2013;71(5):441-6
pubmed: 23788083
Bioessays. 2011 Aug;33(8):574-81
pubmed: 21732396
Curr Hypertens Rep. 2017 Apr;19(4):25
pubmed: 28315048
Hypertension. 2019 May;73(5):998-1006
pubmed: 30905192
Nature. 2016 Jul 06;535(7610):75-84
pubmed: 27383982
High Blood Press Cardiovasc Prev. 2022 Jan;29(1):15-21
pubmed: 34727352
Biomarkers. 2013 Jun;18(4):279-96
pubmed: 23672534
Biochemistry. 1997 Jul 29;36(30):9101-8
pubmed: 9230042
Can J Cardiol. 2014 Dec;30(12):1700-5
pubmed: 25475471
Int J Mol Sci. 2021 Sep 07;22(18):
pubmed: 34575833
Hypertension. 2010 Sep;56(3):437-44
pubmed: 20679181
Mol Cancer Res. 2004 Dec;2(12):692-701
pubmed: 15634758
Exp Ther Med. 2020 Feb;19(2):1479-1484
pubmed: 32010326
Cureus. 2022 Aug 19;14(8):e28165
pubmed: 36148181
Circ Res. 2015 Jan 30;116(3):448-55
pubmed: 25599331
Nature. 2009 Jan 22;457(7228):480-4
pubmed: 19043404
Metabolism. 2015 Apr;64(4):476-81
pubmed: 25676802
Hypertens Res. 2022 Feb;45(2):246-253
pubmed: 34887530
J Hypertens. 2017 Sep;35(9):1899-1908
pubmed: 28509726
Pflugers Arch. 2019 Dec;471(11-12):1441-1453
pubmed: 31728701
Nutr J. 2013 Oct 12;12:138
pubmed: 24120179
Curr Cardiol Rep. 2006 Nov;8(6):411-7
pubmed: 17059792
J Nutr Biochem. 2015 Jun;26(6):651-60
pubmed: 25762527
Cell Metab. 2013 Jan 8;17(1):49-60
pubmed: 23312283
Hypertension. 2021 Aug;78(2):499-511
pubmed: 33966451
Hypertension. 1981 Mar-Apr;3(2):149-56
pubmed: 7216371
Redox Biol. 2021 Oct;46:102115
pubmed: 34474396
Pharmacol Res. 2011 Apr;63(4):308-19
pubmed: 21193045
Cardiovasc Res. 2007 Jan 1;73(1):6-7
pubmed: 17156767
Pharmacol Res. 2020 Mar;153:104663
pubmed: 31987993
J Appl Microbiol. 2019 Dec;127(6):1824-1834
pubmed: 31509634
Front Cell Infect Microbiol. 2017 Aug 24;7:381
pubmed: 28884091
Nutrients. 2019 Nov 07;11(11):
pubmed: 31703257
Front Pharmacol. 2018 May 23;9:533
pubmed: 29875665
Physiol Rev. 1991 Jul;71(3):617-58
pubmed: 2057525
Am J Physiol Gastrointest Liver Physiol. 2001 Oct;281(4):G907-15
pubmed: 11557510
Nutrients. 2022 May 04;14(9):
pubmed: 35565888
Nature. 2011 Apr 7;472(7341):57-63
pubmed: 21475195
Curr Opin Nephrol Hypertens. 2015 Sep;24(5):403-9
pubmed: 26125644
Hypertension. 2014 Oct;64(4):897-903
pubmed: 25047574
Prog Drug Res. 2014;69:15-36
pubmed: 25130038
Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1805-H1820
pubmed: 30265149
Eur Heart J. 2020 Nov 21;41(44):4259-4267
pubmed: 32869053
Clin Sci (Lond). 2018 Mar 30;132(6):701-718
pubmed: 29507058
Rev Endocr Metab Disord. 2019 Dec;20(4):461-472
pubmed: 31707624
Curr Hypertens Rep. 2019 Jun 24;21(8):63
pubmed: 31236708
Biomed Pharmacother. 2019 Aug;116:109040
pubmed: 31170664
Drugs. 1998;56 Suppl 2:1-10
pubmed: 9813737
Int J Med Sci. 2019 Jun 2;16(6):872-881
pubmed: 31337961
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4592-8
pubmed: 20937873
Lancet. 2008 May 3;371(9623):1513-8
pubmed: 18456100
Am J Hypertens. 2013 Feb;26(2):151
pubmed: 23382392
J Lipid Res. 2006 Jun;47(6):1227-37
pubmed: 16522925
Handb Exp Pharmacol. 2009;(191):341-66
pubmed: 19089336
Gut. 2019 Aug;68(8):1439-1449
pubmed: 30377191