Peculiar Ca
Ca2+ homeostasis
ER stress
autophagy
celiac disease
thapsigargin
type 2 transglutaminase
unfolded protein response
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Jan 2023
12 Jan 2023
Historique:
received:
14
10
2022
revised:
02
01
2023
accepted:
05
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
Celiac disease (CD) is an inflammatory intestinal disease caused by the ingestion of gluten-containing cereals by genetically predisposed individuals. Constitutive differences between cells from CD patients and control subjects, including levels of protein phosphorylation, alterations of vesicular trafficking, and regulation of type 2 transglutaminase (TG2), have been reported. In the present work, we investigated how skin-derived fibroblasts from CD and control subjects responded to thapsigargin, an endoplasmic reticulum ER stress inducer, in an attempt to contribute to the comprehension of molecular features of the CD cellular phenotype. We analyzed Ca
Identifiants
pubmed: 36675008
pii: ijms24021495
doi: 10.3390/ijms24021495
pmc: PMC9866799
pii:
doi:
Substances chimiques
Protein Glutamine gamma Glutamyltransferase 2
EC 2.3.2.13
Thapsigargin
67526-95-8
GTP-Binding Proteins
EC 3.6.1.-
Transglutaminases
EC 2.3.2.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondi di Ateneo per la Ricerca di Base", University of Salerno, Italy
ID : ORSA184343
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