The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma.
Humans
Squamous Cell Carcinoma of Head and Neck
/ genetics
Carcinoma, Squamous Cell
/ pathology
Pilot Projects
Head and Neck Neoplasms
/ genetics
Laryngeal Neoplasms
/ metabolism
RNA
RNA-Binding Proteins
/ genetics
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Cell Proliferation
/ genetics
EGFR
RNA-binding proteins
SMN
head and neck cancers
squamous cell carcinoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jan 2023
16 Jan 2023
Historique:
received:
16
12
2022
revised:
11
01
2023
accepted:
13
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
Head and neck squamous cell carcinoma (HNSCC) arises from the mucosal epithelium in the oral cavity, pharynx, sino-nasal region, and larynx. Laryngeal squamous cell carcinoma (LSCC) represents one-third of all head and neck cancers. Dysregulated RNA-related pathways define an important molecular signature in this aggressive carcinoma. The Survival Motor Neuron (SMN) protein regulates fundamental aspects of the RNA metabolism but, curiously, its role in cancer is virtually unknown. For the first time, here, we focus on the SMN in the cancer context. We conducted a pilot study in a total of 20 patients with LSCC where the SMN was found overexpressed at both the protein and transcript levels. By a cellular model of human laryngeal carcinoma, we demonstrated that the SMN impacts cancer-relevant behaviors and perturbs key players of cell migration, invasion, and adhesion. Furthermore, in LSCC we showed a physical interaction between the SMN and the epidermal growth factor receptor (EGFR), whose overexpression is an important feature in these tumors. This study proposes the SMN protein as a novel therapeutic target in LSSC and likely in the whole spectrum of HNSCC. Overall, we provide the first analysis of the SMN in human cancer.
Identifiants
pubmed: 36675308
pii: ijms24021794
doi: 10.3390/ijms24021794
pmc: PMC9864193
pii:
doi:
Substances chimiques
RNA
63231-63-0
RNA-Binding Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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