Deletions across the SARS-CoV-2 Genome: Molecular Mechanisms and Putative Functional Consequences of Deletions in Accessory Genes.
evolution
palindromes
recombination
recurrent deletions
replication
template switch
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
16 Jan 2023
16 Jan 2023
Historique:
received:
21
12
2022
revised:
13
01
2023
accepted:
13
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
The analysis of deletions may reveal evolutionary trends and provide new insight into the surprising variability and rapidly spreading capability that SARS-CoV-2 has shown since its emergence. To understand the factors governing genomic stability, it is important to define the molecular mechanisms of deletions in the viral genome. In this work, we performed a statistical analysis of deletions. Specifically, we analyzed correlations between deletions in the SARS-CoV-2 genome and repetitive elements and documented a significant association of deletions with runs of identical (poly-) nucleotides and direct repeats. Our analyses of deletions in the accessory genes of SARS-CoV-2 suggested that there may be a hypervariability in
Identifiants
pubmed: 36677521
pii: microorganisms11010229
doi: 10.3390/microorganisms11010229
pmc: PMC9862619
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Intramural Research Program of the National Library of Medicine at the National Institutes of Health
ID : N/A
Organisme : Ministry of Education Youth and Sports
ID : SGS/PřF/2023
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