Metabolic Effects and Safety Aspects of Acute D-allulose and Erythritol Administration in Healthy Subjects.
D-allulose
blood lipids
erythritol
ghrelin
glycemic control
healthy subjects
hsCRP
sweeteners
uric acid
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
15 Jan 2023
15 Jan 2023
Historique:
received:
19
12
2022
revised:
06
01
2023
accepted:
11
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
The rapid increase in sugar consumption is associated with various negative metabolic and inflammatory effects; therefore, alternative sweeteners become of interest. The aim of this study was to investigate the metabolic effects and safety aspects of acute D-allulose and erythritol on glucose, insulin, ghrelin, blood lipids, uric acid, and high-sensitive C-reactive protein (hsCRP). In three study visits, 18 healthy subjects received an intragastric administration of 25 g D-allulose or 50 g erythritol, or 300 mL tap water (placebo) in a randomized, double-blind and crossover order. To measure the aforementioned parameters, blood samples were drawn at fixed time intervals. Glucose and insulin concentrations were lower after D-allulose compared to tap water (
Identifiants
pubmed: 36678329
pii: nu15020458
doi: 10.3390/nu15020458
pmc: PMC9863415
pii:
doi:
Substances chimiques
psicose
23140-52-5
Ghrelin
0
Blood Glucose
0
Erythritol
RA96B954X6
C-Reactive Protein
9007-41-4
Uric Acid
268B43MJ25
Fructose
30237-26-4
Glucose
IY9XDZ35W2
Sweetening Agents
0
Insulin
0
Sugars
0
Lipids
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swiss National Science Foundation
ID : 320030E_189329
Pays : Switzerland
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