Acetylsalicylic Acid and Mood Disorders: A Systematic Review.
ASA
acetylsalicylic acid
animal model of depression
animal model of mania
aspirin
bipolar disorder
depressive episode
major depression
mania
mood disorders
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
31 Dec 2022
31 Dec 2022
Historique:
received:
07
11
2022
revised:
01
12
2022
accepted:
28
12
2022
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
The effects of acetylsalicylic acid (ASA) on mood disorders (MD) and on inflammatory parameters in preclinical and clinical studies have not yet been comprehensively evaluated. The aim of this study was to systematically summarize the available knowledge on this topic according to PRISMA guidelines. Data from preclinical and clinical studies were analyzed, considering the safety and efficacy of ASA in the treatment of MD and the correlation of inflammatory parameters with the effect of ASA treatment. Twenty-one studies were included. Both preclinical and clinical studies found evidence indicating the safety and efficacy of low-dose ASA in the treatment of all types of affective episodes in MD. Observational studies have indicated a reduced risk of all types of affective episodes in chronic low-dose ASA users (HR 0.92, 95% CI: 0.88, 0.95, p < 0.0001). An association between ASA response and inflammatory parameters was found in preclinical studies, but this was not confirmed in clinical trials. Further long-term clinical trials evaluating the safety and efficacy of ASA in recurrent MD, as well as assessing the linkage of ASA treatment with inflammatory phenotype and cytokines, are required. There is also a need for preclinical studies to understand the exact mechanism of action of ASA in MD.
Identifiants
pubmed: 36678565
pii: ph16010067
doi: 10.3390/ph16010067
pmc: PMC9861965
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):9-14
pubmed: 19939659
Biol Psychiatry. 2010 Mar 1;67(5):446-57
pubmed: 20015486
Bipolar Disord. 2016 Aug;18(5):440-50
pubmed: 27566286
Int J Neuropsychopharmacol. 2016 Feb 2;19(6):
pubmed: 26839250
Brain Res Brain Res Protoc. 2001 Apr;7(1):11-20
pubmed: 11275519
Braz J Psychiatry. 2020 Nov-Dec;42(6):657-672
pubmed: 32756809
Bipolar Disord. 2013 Sep;15(6):650-6
pubmed: 23924261
Pharmaceutics. 2021 Nov 01;13(11):
pubmed: 34834241
J Affect Disord. 2018 Aug 1;235:124-128
pubmed: 29655073
Curr Top Behav Neurosci. 2017;31:139-154
pubmed: 27221625
ACS Chem Neurosci. 2014 Jun 18;5(6):459-67
pubmed: 24786695
J Clin Psychiatry. 2018 Dec 4;80(1):
pubmed: 30549489
Brain Behav Immun. 2014 Aug;40:219-25
pubmed: 24703991
J Affect Disord. 2011 May;130(3):429-37
pubmed: 21106250
Singapore Med J. 2018 May;59(5):230-239
pubmed: 29796686
PLoS One. 2014 Apr 02;9(4):e91936
pubmed: 24694747
Transl Psychiatry. 2018 Jan 24;8(1):27
pubmed: 29362444
BJU Int. 2007 Jan;99(1):177-82
pubmed: 17034495
Am J Mens Health. 2020 Sep-Oct;14(5):1557988320969082
pubmed: 33111628
Int Clin Psychopharmacol. 2006 Jul;21(4):219-25
pubmed: 16687993
Int Urol Nephrol. 2018 Mar;50(3):411-418
pubmed: 29344879
Neuron. 2020 Jul 22;107(2):234-256
pubmed: 32553197
Psychiatr Pol. 2018 Jun 30;52(3):437-447
pubmed: 30218560
Int Clin Psychopharmacol. 2006 Jul;21(4):227-31
pubmed: 16687994
Curr Opin Psychiatry. 2013 Jan;26(1):19-26
pubmed: 23196997
Aust N Z J Psychiatry. 2016 Jul;50(7):618-30
pubmed: 27091850
World J Clin Cases. 2022 Aug 6;10(22):7872-7882
pubmed: 36158469
Br J Haematol. 2017 Jun;177(5):674-683
pubmed: 28106908
Vascul Pharmacol. 2016 Dec;87:14-22
pubmed: 27765537
J Psychiatr Res. 2017 Jan;84:310-317
pubmed: 27814503
BJU Int. 2001 Jun;87(9):882-8
pubmed: 11412231
Ann Palliat Med. 2021 Jan;10(1):350-361
pubmed: 33440965
Glia. 2013 Jun;61(6):943-56
pubmed: 23505121
J Affect Disord. 2018 Feb;227:219-225
pubmed: 29102836
Mol Psychiatry. 2020 Jan;25(1):94-113
pubmed: 31249382
Acta Psychiatr Scand. 2019 Jan;139(1):68-77
pubmed: 30182363
Front Psychiatry. 2019 Jul 16;10:497
pubmed: 31379619
Expert Opin Drug Metab Toxicol. 2021 Oct;17(10):1199-1210
pubmed: 34632898
BMC Nephrol. 2018 Nov 3;19(1):305
pubmed: 30390660
J Affect Disord. 2015 Aug 15;182:126-31
pubmed: 25985382
Curr Neuropharmacol. 2018;16(5):519-532
pubmed: 28847296
Thrombosis. 2012;2012:245037
pubmed: 22195280
Braz J Psychiatry. 2015 Apr-Jun;37(2):155-61
pubmed: 25946396
Pharmaceutics. 2022 Apr 20;14(5):
pubmed: 35631487
Int J Bipolar Disord. 2015 Dec;3(1):28
pubmed: 26043842
Pharmacol Res. 2021 Jan;163:105325
pubmed: 33278569
J Affect Disord. 2016 Apr;194:120-7
pubmed: 26820761
Res Synth Methods. 2021 Jan;12(1):55-61
pubmed: 32336025
Dement Geriatr Cogn Disord. 2015;40(5-6):311-39
pubmed: 26360014
PLoS Med. 2022 Apr 19;19(4):e1003960
pubmed: 35439243
Mol Psychiatry. 2021 Sep;26(9):5161-5170
pubmed: 33504953
J Affect Disord. 2016 Mar 15;193:203-7
pubmed: 26773921
JAMA Psychiatry. 2020 Oct 1;77(10):1012-1020
pubmed: 32492080
Front Oncol. 2021 Jun 18;11:690219
pubmed: 34277434
J Clin Neurol. 2021 Oct;17(4):503-515
pubmed: 34595858
J Affect Disord. 2015 Jul 15;180:142-7
pubmed: 25909752
Lancet. 2012 Apr 28;379(9826):1591-601
pubmed: 22440947
Bipolar Disord. 2019 Aug;21(5):410-418
pubmed: 30873730
J Biomed Sci. 2021 Jun 11;28(1):45
pubmed: 34112182
Psychopharmacology (Berl). 2020 Nov;237(11):3481-3487
pubmed: 32767039
J Alzheimers Dis Rep. 2021 Aug 10;5(1):647-661
pubmed: 34632302
J Cereb Blood Flow Metab. 2017 Mar;37(3):1060-1068
pubmed: 27178425
BMC Med. 2020 Jan 17;18(1):16
pubmed: 31948461
Brain Sci. 2019 Oct 29;9(11):
pubmed: 31671812
Int J Geriatr Psychiatry. 2018 Feb;33(2):e193-e198
pubmed: 28782132
J Res Med Sci. 2013 Jul;18(7):601-10
pubmed: 24516494
BMJ. 2019 Aug 28;366:l4898
pubmed: 31462531
Psychosom Med. 2022 Jan 1;84(1):97-103
pubmed: 34611111
J Neurol Neurosurg Psychiatry. 2020 Jan;91(1):21-32
pubmed: 31658959
Psychother Psychosom. 2010;79(5):323-5
pubmed: 20689351
Pharmacol Biochem Behav. 2019 Feb;177:12-19
pubmed: 30586559
Eur J Neurosci. 2022 May;55(9-10):2851-2894
pubmed: 33876886
Mol Psychiatry. 2020 Feb;25(2):339-350
pubmed: 31427752
Neurosci Lett. 2011 Jul 20;499(2):74-9
pubmed: 21640159
J Clin Psychiatry. 2017 Sep/Oct;78(8):e980-e985
pubmed: 28767208
Electron Physician. 2017 Nov 25;9(11):5770-5777
pubmed: 29403618
J Psychiatr Res. 2017 Sep;92:160-182
pubmed: 28458141
J Neurosci Res. 2021 Nov;99(11):2976-2998
pubmed: 34346520
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Mar 5;228:117813
pubmed: 31813726
J Affect Disord. 2019 Oct 1;257:640-649
pubmed: 31357161
J Affect Disord. 2017 Mar 15;211:99-106
pubmed: 28107669
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9262-7
pubmed: 21518864
BMJ. 2021 Mar 29;372:n160
pubmed: 33781993
Mol Neurobiol. 2016 Jul;53(5):3258-3266
pubmed: 26059811
Psychiatr Danub. 2017 Sep;29(Suppl 3):270-273
pubmed: 28953776
Brain Behav Immun. 2019 Oct;81:24-40
pubmed: 31195092
Sci Rep. 2019 May 28;9(1):7941
pubmed: 31138859
J Neural Transm (Vienna). 2019 Nov;126(11):1383-1408
pubmed: 31584111
Ecancermedicalscience. 2021 Jul 02;15:1258
pubmed: 34567243
Acta Psychiatr Scand. 2017 May;135(5):373-387
pubmed: 28122130
Brain Behav Immun. 2021 Oct;97:193-203
pubmed: 34332041
Molecules. 2021 May 27;26(11):
pubmed: 34071951
J Affect Disord. 2021 Sep 1;292:642-651
pubmed: 34153835
Pharmacol Biochem Behav. 2014 Sep;124:361-6
pubmed: 25019653
Medicine (Baltimore). 2018 Jul;97(28):e11367
pubmed: 29995772