Inhalable Polymeric Nanoparticles for Pulmonary Delivery of Antimicrobial Peptide SET-M33: Antibacterial Activity and Toxicity In Vitro and In Vivo.
Pseudomonas aeruginosa
aerosolization
antimicrobial peptides
antimicrobial resistance
inhalable formulations
lung delivery
nanoparticle properties
nanoparticle/mucus interactions
polymeric nanoparticles
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
20 Dec 2022
20 Dec 2022
Historique:
received:
11
10
2022
revised:
12
12
2022
accepted:
14
12
2022
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
Development of inhalable formulations for delivering peptides to the conductive airways and shielding their interactions with airway barriers, thus enhancing peptide/bacteria interactions, is an important part of peptide-based drug development for lung applications. Here, we report the construction of a biocompatible nanosystem where the antimicrobial peptide SET-M33 is encapsulated within polymeric nanoparticles of poly(lactide-co-glycolide) (PLGA) conjugated with polyethylene glycol (PEG). This system was conceived for better delivery of the peptide to the lungs by aerosol. The encapsulated peptide showed prolonged antibacterial activity, due to its controlled release, and much lower toxicity than the free molecule. The peptide-based nanosystem killed
Identifiants
pubmed: 36678633
pii: pharmaceutics15010003
doi: 10.3390/pharmaceutics15010003
pmc: PMC9863998
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondazione Italiana Fibrosi Cistica
ID : FFC#17/2016
Organisme : Regione Toscana
ID : APICECUPI69C20000320002
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