Folic Acid-Grafted Chitosan-Alginate Nanocapsules as Effective Targeted Nanocarriers for Delivery of Turmeric Oil for Breast Cancer Therapy.
Box-Behnken design
breast cancer
chitosan-alginate nanocapsules
cytotoxicity
folate receptor
targeted delivery
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
28 Dec 2022
28 Dec 2022
Historique:
received:
25
11
2022
revised:
20
12
2022
accepted:
23
12
2022
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
22
1
2023
Statut:
epublish
Résumé
Folate receptors (FRs) highly expressed in breast cancers can be used as a recognized marker for preventing off-target delivery of chemotherapeutics. In this study, folic acid (FA)-grafted chitosan-alginate nanocapsules (CS-Alg-NCs) loaded with turmeric oil (TO) were developed for breast cancer targeting. CS was successfully conjugated with FA via an amide bond with a degree of substitution at 12.86%. The TO-loaded FA-grafted CS-Alg-NCs (TO-FA-CS-Alg-NCs) optimized by Box-Behnken design using response surface methodology had satisfactory characteristics with homogenous particle size (189 nm) and sufficient encapsulation efficiency and loading capacity (35.9% and 1.82%, respectively). In vitro release study of the optimized TO-FA-CS-Alg-NCs showed a sustained TO release following the Korsmeyer-Peppas model with a Fickian diffusion mechanism at pH 5.5 and 7.4. The TO-FA-CS-Alg-NCs showed lower IC
Identifiants
pubmed: 36678739
pii: pharmaceutics15010110
doi: 10.3390/pharmaceutics15010110
pmc: PMC9862360
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund)
Organisme : The Ratchadaphiseksomphot Endowment Fund for supporting the Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University
ID : GCE 6503433003-1
Organisme : The Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University
ID : RCU_H_64_035_62
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