Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro.

ABT-737 C19orf12 LC3 LY294002 autophagy carbamazepine mitochondria membrane protein-associated neurodegeneration (MPAN) neurodegeneration with brain iron accumulation (NBIA) oridonin paroxetine

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
12 Jan 2023
Historique:
received: 25 11 2022
revised: 05 01 2023
accepted: 09 01 2023
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 22 1 2023
Statut: epublish

Résumé

Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a relentlessly progressive neurodegenerative disorder caused by mutations in the

Identifiants

pubmed: 36678896
pii: pharmaceutics15010267
doi: 10.3390/pharmaceutics15010267
pmc: PMC9862353
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Enrica Zanuttigh (E)

Institute of Neurogenomics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

Kevork Derderian (K)

Institute of Neurogenomics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

Miriam A Güra (MA)

Institute of Neurogenomics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

Arie Geerlof (A)

Protein Expression and Purification Facility, Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

Ivano Di Meo (I)

Medical Genetics and Neurogenetics Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126 Milan, Italy.

Chiara Cavestro (C)

Medical Genetics and Neurogenetics Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126 Milan, Italy.

Stefan Hempfling (S)

Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Bavarian NMR Centre, Department of Bioscience, School of Natural Sciences, Technical University of Munich, 85747 Garching, Germany.

Stephanie Ortiz-Collazos (S)

Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Bavarian NMR Centre, Department of Bioscience, School of Natural Sciences, Technical University of Munich, 85747 Garching, Germany.

Mario Mauthe (M)

Molecular Cell Biology Section, Department of Biomedical Sciences of Cells & Systems, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands.
Expertise Center Movement Disorders Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands.

Tomasz Kmieć (T)

Department of Neurology and Epileptology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.

Eugenia Cammarota (E)

Alembic, Experimental Imaging Center, IRCCS San Raffaele Hospital, 20132 Milan, Italy.

Maria Carla Panzeri (MC)

Alembic, Experimental Imaging Center, IRCCS San Raffaele Hospital, 20132 Milan, Italy.

Thomas Klopstock (T)

Department of Neurology, Friedrich-Baur-Institute, University Hospital of the Ludwig-Maximilians-University (LMU), 80336 Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.

Michael Sattler (M)

Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Bavarian NMR Centre, Department of Bioscience, School of Natural Sciences, Technical University of Munich, 85747 Garching, Germany.

Juliane Winkelmann (J)

Institute of Neurogenomics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Institute of Human Genetics, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

Ana C Messias (AC)

Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Bavarian NMR Centre, Department of Bioscience, School of Natural Sciences, Technical University of Munich, 85747 Garching, Germany.

Arcangela Iuso (A)

Institute of Neurogenomics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Institute of Human Genetics, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

Classifications MeSH