The Combined Anti-Tumor Efficacy of Bioactive Hydroxyapatite Nanoparticles Loaded with Altretamine.

altretamine cancer therapy chemical precipitation method hydroxyapatite nanoparticles sustained delivery

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
16 Jan 2023
Historique:
received: 17 11 2022
revised: 29 12 2022
accepted: 10 01 2023
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 22 1 2023
Statut: epublish

Résumé

In the current study, the combined anti-tumor efficacy of bioactive hydroxyapatite nano- particles (HA-NPs) loaded with altretamine (ALT) was evaluated. The well-known fact that HA has great biological compatibility was confirmed through the findings of the hemolytic experiments and a maximum IC

Identifiants

pubmed: 36678930
pii: pharmaceutics15010302
doi: 10.3390/pharmaceutics15010302
pmc: PMC9861632
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deanship of Scientific Research at King Khalid University, grant number
ID : RGP2/89/43
Organisme : AlMaarefa Researchers Supporting program, AlMaarefa University, Ri-yadh, Saudi Arabia
ID : TUMA-Project-2021-18

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Auteurs

Yahia Alghazwani (Y)

Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.

Krishnaraju Venkatesan (K)

Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.

Kousalya Prabahar (K)

Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.

Mohamed El-Sherbiny (M)

Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh 13713, Saudi Arabia.
Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Nehal Elsherbiny (N)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.
Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Mona Qushawy (M)

Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.
Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Alarish 45511, Egypt.

Classifications MeSH