Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia.

Humans Schizophrenia / diagnostic imaging Anhedonia Brain / diagnostic imaging Mood Disorders Motivation
ALFF Avolition Negative symptoms

Journal

Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001

Informations de publication

Date de publication:
03 2023
Historique:
received: 07 09 2022
revised: 30 12 2022
accepted: 10 01 2023
pubmed: 22 1 2023
medline: 14 2 2023
entrez: 21 1 2023
Statut: ppublish

Résumé

This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

Identifiants

DOI: 10.1016/j.pscychresns.2023.111597 PMID: 36680843
pubmed: 36680843
pii: S0925-4927(23)00007-0
doi: 10.1016/j.pscychresns.2023.111597
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

111597

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB015611
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS114628
Pays : United States
Organisme : NCRR NIH HHS
ID : U24 RR021992
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118695
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH123163
Pays : United States
Organisme : NIH HHS
ID : S10 OD023696
Pays : United States
Organisme : NCRR NIH HHS
ID : U24 RR025736
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121246
Pays : United States

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest Dr. Daniel H. Mathalon consulted for Neurocrine Biosciences, Gilgamesh Pharmaceuticals, and Recognify Life Sciences, and served on a data safety monitoring/advisory board for Neurocrine Biosciences. The other authors have no conflict of interest to report.

Auteurs

Eun-Jin Cheon (EJ)

Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Department of Psychiatry, Yeungnam University College of Medicine, Daegu, South Korea.

Alie G Male (AG)

Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.

Bingchen Gao (B)

Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.

Bhim M Adhikari (BM)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.

Jesse T Edmond (JT)

Center for Translational Research in Neuroimaging and Data Science (TReNDS), GSU/GATech/Emory, Atlanta, GA, United States.

Stephanie M Hare (SM)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.

Aysenil Belger (A)

Department of Psychiatry, University of North Carolina, Chapel Hill, United States.

Steven G Potkin (SG)

Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.

Juan R Bustillo (JR)

Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM, United States.

Daniel H Mathalon (DH)

Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, United States; Veterans Affairs San Francisco Healthcare System, San Francisco, CA, United States.

Judith M Ford (JM)

Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, United States; Veterans Affairs San Francisco Healthcare System, San Francisco, CA, United States.

Kelvin O Lim (KO)

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.

Bryon A Mueller (BA)

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.

Adrian Preda (A)

Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.

Daniel O'Leary (D)

Department of Psychiatry, University of Iowa, IA, United States.

Gregory P Strauss (GP)

Department of Psychology, University of Georgia, Athens, GA, United States.

Anthony O Ahmed (AO)

Department of Psychiatry, Weill Cornell Medicine, White Plains, NY, United States.

Paul M Thompson (PM)

Imaging Genetics Center, University of Southern California, Marina del Rey, CA, United States.

Neda Jahanshad (N)

Imaging Genetics Center, University of Southern California, Marina del Rey, CA, United States.

Peter Kochunov (P)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.

Vince D Calhoun (VD)

Center for Translational Research in Neuroimaging and Data Science (TReNDS), GSU/GATech/Emory, Atlanta, GA, United States.

Jessica A Turner (JA)

Department of Psychiatry, Ohio State University, OH, United States.

Theo G M van Erp (TGM)

Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, United States. Electronic address: tvanerp@uci.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Five negative symptom domains are...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Five negative symptom domains are...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Anhédonie › Five negative symptom domains are...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Five negative symptom domains are...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Five negative symptom domains are...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Personnalité › Intelligence › Intelligence émotionnelle › Motivation › Five negative symptom domains are...