Dorsal anterior cingulate cortex activity during cognitive challenge in social anxiety disorder.

Humans Phobia, Social / diagnostic imaging Gyrus Cinguli / diagnostic imaging Emotions Anxiety Disorders / diagnostic imaging Cognition Magnetic Resonance Imaging
Anterior cingulate cortex Functional magnetic resonance imaging Social anxiety disorder

Journal

Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872

Informations de publication

Date de publication:
28 03 2023
Historique:
received: 09 05 2022
revised: 16 01 2023
accepted: 17 01 2023
pubmed: 22 1 2023
medline: 16 2 2023
entrez: 21 1 2023
Statut: ppublish

Résumé

Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT). Here, we used fMRI to compare dACC activity and test performance during MSIT in 69 SAD patients and 38 healthy controls. In addition to patient-control comparisons, we examined whether neural activity in the dACC correlated with social anxiety, trait anxiety or depression levels. The MSIT activated the dACC as expected but with no differences in task performance or neural reactivity between SAD patients and controls. There were no significant correlations between dACC activity and social or trait anxiety symptom severity. In patients, there was a significant negative correlation between dACC activity and depressive symptoms. In absence of affective challenge, we found no disorder-related cognitive profile in SAD patients since neither MSIT task performance nor dACC neural activity deviated in patients relative to controls.

Sections du résumé

BACKGROUND
Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT).
METHODS
Here, we used fMRI to compare dACC activity and test performance during MSIT in 69 SAD patients and 38 healthy controls. In addition to patient-control comparisons, we examined whether neural activity in the dACC correlated with social anxiety, trait anxiety or depression levels.
RESULTS
The MSIT activated the dACC as expected but with no differences in task performance or neural reactivity between SAD patients and controls. There were no significant correlations between dACC activity and social or trait anxiety symptom severity. In patients, there was a significant negative correlation between dACC activity and depressive symptoms.
CONCLUSIONS
In absence of affective challenge, we found no disorder-related cognitive profile in SAD patients since neither MSIT task performance nor dACC neural activity deviated in patients relative to controls.

Identifiants

DOI: 10.1016/j.bbr.2023.114304 PMID: 36681164
pubmed: 36681164
pii: S0166-4328(23)00022-0
doi: 10.1016/j.bbr.2023.114304
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114304

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declarations of interest None.

Auteurs

Magdalena Wlad (M)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Electronic address: magdalena.wlad@neuro.uu.se.

Andreas Frick (A)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Electronic address: andreas.frick@neuro.uu.se.

Jonas Engman (J)

Department of Psychology, Uppsala University, Uppsala, Sweden. Electronic address: jonas.engman@akademiska.se.

Olof Hjorth (O)

Department of Psychology, Uppsala University, Uppsala, Sweden. Electronic address: olof.hjorth@psyk.uu.se.

Johanna M Hoppe (JM)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Electronic address: johanna.motilla_hoppe@neuro.uu.se.

Vanda Faria (V)

Department of Psychology, Uppsala University, Uppsala, Sweden; Brain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Otorhinolaryngology, Smell & Taste Clinic, TU Dresden, Dresden, Germany. Electronic address: vanda.faria@psyk.uu.se.

Kurt Wahlstedt (K)

Department of Psychology, Uppsala University, Uppsala, Sweden. Electronic address: kurt.wahlstedt@telia.com.

Johannes Björkstrand (J)

Department of Psychology, Lund University, Lund, Sweden. Electronic address: johannes.bjorkstrand@psy.lu.se.

Kristoffer Nt Månsson (KN)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: kristoffer.mansson@ki.se.

Sara Hultberg (S)

Department of Psychology, Uppsala University, Uppsala, Sweden. Electronic address: SaraHultberg_89@hotmail.com.

Iman Alaie (I)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: iman.alaie@neuro.uu.se.

Jörgen Rosén (J)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: jorgen.rosen@ki.se.

Mats Fredrikson (M)

Department of Psychology, Uppsala University, Uppsala, Sweden. Electronic address: mats.fredrikson@psyk.uu.se.

Tomas Furmark (T)

Department of Psychology, Uppsala University, Uppsala, Sweden. Electronic address: tomas.furmark@psyk.uu.se.

Malin Gingnell (M)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Department of Psychology, Uppsala University, Uppsala, Sweden. Electronic address: malin.gingnell@psyk.uu.se.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dorsal anterior cingulate cortex activity...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Troubles phobiques › Phobie sociale › Dorsal anterior cingulate cortex activity...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe limbique › Gyrus du cingulum › Dorsal anterior cingulate cortex activity...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dorsal anterior cingulate cortex activity...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Dorsal anterior cingulate cortex activity...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Dorsal anterior cingulate cortex activity...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Dorsal anterior cingulate cortex activity...