Genetic regulators of cytokine responses upon BCG vaccination in children from West Africa.

Infant, Newborn Infant Humans Child BCG Vaccine / genetics Cytokines / genetics Africa, Western Vaccination
BCG Cytokines Genetic variation Immunogenomics QTL West Africa

Journal

Journal of genetics and genomics = Yi chuan xue bao
ISSN: 1673-8527
Titre abrégé: J Genet Genomics
Pays: China
ID NLM: 101304616

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 13 11 2022
revised: 21 12 2022
accepted: 03 01 2023
medline: 19 6 2023
pubmed: 22 1 2023
entrez: 21 1 2023
Statut: ppublish

Résumé

Genetic variation is a key factor influencing cytokine production capacity, but which genetic loci regulate cytokine production before and after vaccination, particularly in African population is unknown. Here, we aimed to identify single-nucleotide polymorphisms (SNPs) controlling cytokine responses after microbial stimulation in infants of West-African ancestry, comprising of low-birth-weight neonates randomized to bacillus Calmette-Guérin (BCG) vaccine-at-birth or to the usual delayed BCG. Genome-wide cytokine cytokine quantitative trait loci (cQTL) mapping revealed 12 independent loci, of which the LINC01082-LINC00917 locus influenced more than half of the cytokine-stimulation pairs assessed. Furthermore, nine distinct cQTLs were found among infants randomized to BCG. Functional validation confirmed that several complement genes affect cytokine response after BCG vaccination. We observed a limited overlap of common cQTLs between the West-African infants and cohorts of Western European individuals. These data reveal strong population-specific genetic effects on cytokine production and may indicate new opportunities for therapeutic intervention and vaccine development in African populations.

Identifiants

DOI: 10.1016/j.jgg.2023.01.002 PMID: 36681271
pubmed: 36681271
pii: S1673-8527(23)00008-5
doi: 10.1016/j.jgg.2023.01.002
pii:
doi:

Substances chimiques

BCG Vaccine 0
Cytokines 0

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

434-446

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors have no competing interests to declare.

Auteurs

Collins K Boahen (CK)

Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.

S J C F M Moorlag (SJCFM)

Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.

Kristoffer Jarlov Jensen (KJ)

Odense Patient Data Explorative Network, University of Southern Denmark/Odense University Hospital, Odense, DK-5000, Denmark; Center for Clinical Research and Prevention, Frederiksberg and Bispebjerg Hospital, DK-2000, Frederiksberg, Denmark.

Vasiliki Matzaraki (V)

Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.

Stephanie Fanucchi (S)

Lemba Therapeutics, Nijmegen, 6525 GA, the Netherlands.

Ivan Monteiro (I)

Bandim Health Project, Indepth Network, Bissau, codex 1004, Guinea-Bissau.

Charlotte de Bree (C)

Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.

Ezio T Fok (ET)

Epigenomics & Single Cell Biophysics Group, Department of Cell Biology FNWI, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, 6525 HP, the Netherlands; Department of Human Genetics, Radboud University Medical Center, 6525 HP, the Netherlands.

Musa Mhlanga (M)

Epigenomics & Single Cell Biophysics Group, Department of Cell Biology FNWI, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, 6525 HP, the Netherlands; Department of Human Genetics, Radboud University Medical Center, 6525 HP, the Netherlands.

Leo A B Joosten (LAB)

Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.

Peter Aaby (P)

Odense Patient Data Explorative Network, University of Southern Denmark/Odense University Hospital, Odense, DK-5000, Denmark; Bandim Health Project, Statens Serum Institut, Copenhagen S, DK-2300, Denmark.

Christine Stabell Benn (CS)

Odense Patient Data Explorative Network, University of Southern Denmark/Odense University Hospital, Odense, DK-5000, Denmark; Danish Institute for Advanced Study, University of Southern Denmark, Odense, DK-5000, Denmark.

Mihai G Netea (MG)

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Germany.

Vinod Kumar (V)

Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, 9700 RB, the Netherlands; Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Medical Sciences Complex, Deralakatte, Mangalore, 575018, India. Electronic address: v.kumar@radboudumc.nl.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Genetic regulators of cytokine responses upon...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Genetic regulators of cytokine responses upon...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic regulators of cytokine responses upon...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Genetic regulators of cytokine responses upon...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Vaccins antituberculeux › Vaccin BCG › Genetic regulators of cytokine responses upon...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Genetic regulators of cytokine responses upon...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique de l'Ouest › Genetic regulators of cytokine responses upon...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Genetic regulators of cytokine responses upon...