Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
21 01 2023
Historique:
received: 23 03 2022
accepted: 23 12 2022
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 25 1 2023
Statut: epublish

Résumé

Aberrant Wnt activation has been reported in failing cardiomyocytes. Here we present single cell transcriptome profiling of hearts with inducible cardiomyocyte-specific Wnt activation (β-cat

Identifiants

pubmed: 36681760
doi: 10.1038/s42003-022-04402-9
pii: 10.1038/s42003-022-04402-9
pmc: PMC9867722
doi:

Substances chimiques

Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

79

Informations de copyright

© 2023. The Author(s).

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Auteurs

Eric Schoger (E)

Institute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.
Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, 37075, Göttingen, Germany.

Federico Bleckwedel (F)

Institute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.

Giulia Germena (G)

German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.
Laboratory Animal Science Unit, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, 37075, Göttingen, Germany.

Cheila Rocha (C)

Laboratory Animal Science Unit, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, 37075, Göttingen, Germany.

Petra Tucholla (P)

Institute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.

Izzatullo Sobitov (I)

Institute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.

Wiebke Möbius (W)

Max-Planck-Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.

Maren Sitte (M)

NGS Integrative Genomics Core Unit (NIG), University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.

Christof Lenz (C)

Department of Clinical Chemistry, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.

Mostafa Samak (M)

German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.
Laboratory Animal Science Unit, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, 37075, Göttingen, Germany.

Rabea Hinkel (R)

German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.
Laboratory Animal Science Unit, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, 37075, Göttingen, Germany.
Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour (ITTN), Stiftung Tierärztliche Hochschule Hannover, University of Veterinary Medicine, 30173, Hannover, Germany.

Zoltán V Varga (ZV)

HCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1085, Budapest, Hungary.
Pharmahungary Group, H-1085, Budapest, Hungary.

Zoltán Giricz (Z)

HCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1085, Budapest, Hungary.
Pharmahungary Group, H-1085, Budapest, Hungary.

Gabriela Salinas (G)

NGS Integrative Genomics Core Unit (NIG), University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.

Julia C Gross (JC)

Health and Medical University, D-14471, Potsdam, Germany.

Laura C Zelarayán (LC)

Institute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany. laura.zelarayan@med.uni-goettingen.de.
German Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany. laura.zelarayan@med.uni-goettingen.de.
Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, 37075, Göttingen, Germany. laura.zelarayan@med.uni-goettingen.de.

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