Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice.

Mice Animals Plant Extracts / pharmacology Gastrodia Proto-Oncogene Proteins c-akt Brain-Derived Neurotrophic Factor Weightlessness Cognitive Dysfunction / drug therapy
Cognitive impairment Gastrodia elata blume Hindlimb suspension Mice Neuroprotection Simulated weightlessness

Journal

Life sciences in space research
ISSN: 2214-5532
Titre abrégé: Life Sci Space Res (Amst)
Pays: Netherlands
ID NLM: 101632373

Informations de publication

Date de publication:
Feb 2023
Historique:
received: 15 06 2022
revised: 19 09 2022
accepted: 02 10 2022
entrez: 22 1 2023
pubmed: 23 1 2023
medline: 25 1 2023
Statut: ppublish

Résumé

During the long-term orbital flight, exposure to microgravity negatively affects the astronauts' development of cognition, characterized by learning and memory decline. Gastrodia elata Blume (GEB) has a significant protective effect on cognitive impairment and has been used in Asia for centuries as a functional product. A previous study demonstrated that GEB could improve memory loss in mice caused by circadian rhythm disorders. However, the effects of GEB on cognitive dysfunction caused by weightless environments have not been investigated. In this study, mice received daily treatment with GEB (0.5, 1 g·kg

Identifiants

DOI: 10.1016/j.lssr.2022.10.001 PMID: 36682818
pubmed: 36682818
pii: S2214-5524(22)00075-X
doi: 10.1016/j.lssr.2022.10.001
pii:
doi:

Substances chimiques

Plant Extracts 0
Proto-Oncogene Proteins c-akt EC 2.7.11.1
Brain-Derived Neurotrophic Factor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-7

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Fang Chen (F)

Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; Hunan University of Chinese Medicine, Hunan 410000, China.

Ning Jiang (N)

Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.

Yi Wen Zhang (YW)

Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.

Meng Zhou Xie (MZ)

Hunan University of Chinese Medicine, Hunan 410000, China. Electronic address: xiemz@163.com.

Xin Min Liu (XM)

Institute of New Drug Technology, Ningbo University, Ningbo 315000, China; Hunan University of Chinese Medicine, Hunan 410000, China. Electronic address: liuxinmin@hotmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protective effect of Gastrodia elata blume...
questionsmedicales.fr › Eucaryotes › Animaux › Protective effect of Gastrodia elata blume...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Protective effect of Gastrodia elata blume...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Orchidaceae › Gastrodia › Protective effect of Gastrodia elata blume...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Protective effect of Gastrodia elata blume...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Protective effect of Gastrodia elata blume...
questionsmedicales.fr › Phénomènes physiques › Phénomènes astronomiques › Gravitation › Pesanteur modifiée › Sous-pesanteur › Impesanteur › Protective effect of Gastrodia elata blume...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Protective effect of Gastrodia elata blume...