Systemic structural analysis of alterations reveals a common structural basis of driver mutations in cancer.
Journal
NAR cancer
ISSN: 2632-8674
Titre abrégé: NAR Cancer
Pays: England
ID NLM: 101769553
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
21
06
2022
revised:
17
10
2022
accepted:
04
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
A major effort in cancer research is to organize the complexities of the disease into fundamental traits. Despite conceptual progress in the last decades and the synthesis of hallmark features, no organizing principles governing cancer beyond cellular features exist. We analyzed experimentally determined structures harboring the most significant and prevalent driver missense mutations in human cancer, covering 73% (
Identifiants
pubmed: 36683915
doi: 10.1093/narcan/zcac040
pii: zcac040
pmc: PMC9846427
doi:
Types de publication
Journal Article
Langues
eng
Pagination
zcac040Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of NAR Cancer.
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