Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms.
gyrification
hostility
magnetic resonance imaging
neuroimaging
psychosis
schizophrenia
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
11
2022
accepted:
12
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
Interest in identifying the clinical implications of the neuropathophysiological background of schizophrenia is rising, including changes in cortical gyrification that may be due to neurodevelopmental abnormalities. Inpatients with schizophrenia can show abnormal gyrification of cortical regions correlated with the symptom severity. Our study included 36 patients that suffered an acute episode of schizophrenia and have undergone structural magnetic resonance imaging (MRI) to calculate the local gyrification index (LGI). In the whole sample, the severity of symptoms significantly correlated with higher LGI in different cortical areas, including bilateral frontal, cingulate, parietal, temporal cortices, and right occipital cortex. Among these areas, patients with low hostility symptoms (LHS) compared to patients with high hostility symptoms (HHS) showed significantly lower LGI related to the severity of symptoms in bilateral frontal and temporal lobes. The severity of psychopathology correlated with higher LGI in large portions of the cerebral cortex, possibly expressing abnormal neural development in schizophrenia. These findings could pave the way for further studies and future tailored diagnostic and therapeutic strategies.
Identifiants
pubmed: 36684000
doi: 10.3389/fpsyt.2022.1092784
pmc: PMC9846757
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1092784Informations de copyright
Copyright © 2023 Ferracuti, Del Casale, Romano, Gualtieri, Lucignani, Napolitano, Modesti, Buscajoni, Zoppi, Kotzalidis, Manelfi, de Pisa, Girardi, Mandarelli, Parmigiani, Rossi-Espagnet, Pompili and Bozzao.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. In the last three years, PG has received consultation fees from Angelini, Janssen, Lundbeck, and Otsuka, which did not influence the content of this manuscript. MP has received lecture or advisory board honoraria or engaged in clinical trial activities with Angelini, Lundbeck, Janssen, Otsuka, Italfarmaco, and Allergan, which did not influence the content of this manuscript. ADC has received lecture or advisory board honoraria or engaged in clinical trial activities with Fidia that did not influence the content of this manuscript.
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