Are Alzheimer's and coronary artery diseases genetically related to longevity?
Alzheimer's disease
coronary artery disease
longevity
pleiotropy
subset-based analysis (ASSET)
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
11
2022
accepted:
12
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
In the last decade researchers have attempted to investigate the shared genetic architecture of longevity and age-related diseases and assess whether the increased longevity in certain people is due to protective alleles in the risk genes for a particular condition or whether there are specific "longevity" genes increasing the lifespan independently of age-related conditions' risk genes. The aim of this study was to investigate the shared genetic component between longevity and two age-related conditions. We performed a cross-trait meta-analysis of publicly available genome-wide data for Alzheimer's disease, coronary artery disease and longevity using a subset-based approach provided by the R package ASSET. Despite the lack of strong genetic correlation between longevity and the two diseases, we identified 38 genome-wide significant lead SNPs across 22 independent genomic loci. Of them 6 were found to be potentially shared among the three traits mapping to genes including In summary, we have been able to advance in the knowledge of the genetic overlap existing among longevity and the two most common age-related disorders.
Identifiants
pubmed: 36684006
doi: 10.3389/fpsyt.2022.1102347
pmc: PMC9859055
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1102347Subventions
Organisme : Medical Research Council
ID : MR/T033371/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801418
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T04604X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P005748/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Informations de copyright
Copyright © 2023 Bellou and Escott-Price.
Déclaration de conflit d'intérêts
VE-P has collaborated with Eisai through their Eisai-DRI collaborative grant funding. EB was supported by Eisai Ltd and UK DRI.
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