Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells.
ApoB
P6
atherosclerosis vaccine
regulatory T cells
single-cell RNA-sequencing
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
10
2022
accepted:
05
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
Atherosclerotic cardiovascular diseases are the major cause of death worldwide. CD4 T cells responding to Apolipoprotein B (ApoB), the core protein of most lipoproteins, have been identified as critical disease modulators. In healthy individuals, ApoB-reactive (ApoB
Identifiants
pubmed: 36684560
doi: 10.3389/fcvm.2022.1076808
pmc: PMC9849899
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1076808Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL136275
Pays : United States
Informations de copyright
Copyright © 2023 Nettersheim, Ghosheh, Winkels, Kobiyama, Durant, Armstrong, Brunel, Roy, Dileepan, Jenkins, Zajonc and Ley.
Déclaration de conflit d'intérêts
KL was founder and co-owner of Atherovax, Inc. He received no compensation from Atherovax. No Atherovax funds were used in this study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Immunol. 2016 Mar;16(3):149-63
pubmed: 26875830
Nat Rev Immunol. 2011 Nov 11;11(12):823-36
pubmed: 22076556
Immunity. 2014 Apr 17;40(4):569-81
pubmed: 24745333
J Am Coll Cardiol. 2019 Apr 9;73(13):1691-1706
pubmed: 30947923
Nat Biotechnol. 2018 Dec 03;:
pubmed: 30531897
Scand J Immunol. 2009 Oct;70(4):326-36
pubmed: 19751267
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6400-E6409
pubmed: 28698369
J Immunol. 1995 Aug 1;155(3):1151-64
pubmed: 7636184
Nat Rev Cardiol. 2020 Aug;17(8):451-452
pubmed: 32587346
Science. 2015 Aug 28;349(6251):989-93
pubmed: 26160380
J Immunol. 2014 May 1;192(9):4017-23
pubmed: 24748636
Nucleic Acids Res. 2017 Sep 19;45(16):e148
pubmed: 28934479
J Immunol. 2019 Feb 15;202(4):1039-1044
pubmed: 30642977
Mucosal Immunol. 2016 Mar;9(2):444-57
pubmed: 26307665
Nat Protoc. 2014 Jan;9(1):171-81
pubmed: 24385147
Science. 2003 Feb 14;299(5609):1057-61
pubmed: 12522256
Immunity. 2014 Oct 16;41(4):529-42
pubmed: 25367570
Circ Res. 2016 May 13;118(10):1540-52
pubmed: 27021296
Genomics Proteomics Bioinformatics. 2021 Apr;19(2):253-266
pubmed: 33662621
Immunity. 2008 Mar;28(3):324-34
pubmed: 18308592
J Exp Med. 1998 Jul 20;188(2):287-96
pubmed: 9670041
Circ Res. 2016 Nov 11;119(11):1190-1203
pubmed: 27635087
Cells. 2021 Feb 19;10(2):
pubmed: 33669769
Immunity. 2007 Aug;27(2):203-13
pubmed: 17707129
Nat Methods. 2016 Apr;13(4):329-332
pubmed: 26950746
Eur J Immunol. 2018 Sep;48(9):1580-1587
pubmed: 29932463
J Clin Invest. 2011 Nov;121(11):4503-15
pubmed: 21965331
Circulation. 2020 Sep 29;142(13):1279-1293
pubmed: 32703007
Nat Commun. 2016 Sep 01;7:12596
pubmed: 27581382
Annu Rev Immunol. 2003;21:713-58
pubmed: 12500979
Nat Rev Immunol. 2014 Jun;14(6):377-91
pubmed: 24830344
Comput Struct Biotechnol J. 2021 Jan 21;19:860-868
pubmed: 33598101
Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H781-H790
pubmed: 28087520
Nat Methods. 2013 Nov;10(11):1096-8
pubmed: 24056875
Cell Rep. 2017 Sep 19;20(12):2906-2920
pubmed: 28889989
Nat Rev Immunol. 2022 Apr;22(4):251-265
pubmed: 34389841
Nat Med. 2006 Feb;12(2):178-80
pubmed: 16462800
Science. 2009 Aug 28;325(5944):1142-6
pubmed: 19696312
Nucleic Acids Res. 2019 Jul 2;47(W1):W191-W198
pubmed: 31066453
Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2387-2398
pubmed: 34320835
Cells. 2020 Nov 30;9(12):
pubmed: 33266027
Nat Rev Cardiol. 2020 Jul;17(7):387-401
pubmed: 32203286
Front Cardiovasc Med. 2022 Jan 13;8:812769
pubmed: 35097028
Nat Cardiovasc Res. 2022 May;1(5):462-475
pubmed: 35990517
Science. 2008 Oct 10;322(5899):271-5
pubmed: 18845758
Nature. 2007 Feb 22;445(7130):931-5
pubmed: 17237765
J Intern Med. 2011 May;269(5):546-56
pubmed: 21114693
Circulation. 2018 Sep 11;138(11):1130-1143
pubmed: 29588316
Immunity. 2019 Feb 19;50(2):493-504.e7
pubmed: 30737144
J Clin Invest. 2013 Mar;123(3):1323-34
pubmed: 23426179
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Cell. 1997 May 16;89(4):587-96
pubmed: 9160750
BMC Bioinformatics. 2015 Jul 19;16:224
pubmed: 26187896
Immunity. 2013 Nov 14;39(5):949-62
pubmed: 24238343
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Bioinformatics. 2017 Feb 1;33(3):425-427
pubmed: 28172415
J Exp Med. 2010 May 10;207(5):1081-93
pubmed: 20439543
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761
pubmed: 29155950
Eur J Immunol. 2013 Sep;43(9):2421-9
pubmed: 23722868
Science. 2015 Oct 16;350(6258):334-9
pubmed: 26472910
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Trends Mol Med. 2011 Nov;17(11):668-76
pubmed: 21890412
Front Immunol. 2018 Oct 23;9:2425
pubmed: 30405621
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Front Immunol. 2017 Feb 23;8:95
pubmed: 28280493
Cell. 2017 Jun 1;169(6):1130-1141.e11
pubmed: 28552348
PLoS One. 2013;8(3):e58364
pubmed: 23505495
Immunogenetics. 2013 Oct;65(10):711-24
pubmed: 23900783
J Clin Invest. 2004 Nov;114(10):1372-8
pubmed: 15545984
Cell. 2006 Sep 22;126(6):1121-33
pubmed: 16990136
Methods Mol Biol. 2018;1799:275-302
pubmed: 29956159