Construction and Analysis of Hepatocellular Carcinoma Prognostic Model Based on Random Forest.
Journal
Canadian journal of gastroenterology & hepatology
ISSN: 2291-2797
Titre abrégé: Can J Gastroenterol Hepatol
Pays: Egypt
ID NLM: 101623613
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
11
2022
revised:
13
12
2022
accepted:
26
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
Transcriptome data and clinical data of HCC were downloaded from the TCGA database. Screen important genes based on the random forest method, combined with differential expression genes (DEGs) to screen out important DEGs. The Kaplan‒Meier curve was used to evaluate its prognostic significance. Cox regression analysis was used to construct a survival prognosis prediction model, and the ROC curve was used to verify it. Finally, the mechanism of action was explored through GO and KEGG pathway enrichment and GeneMANIA coexpression analyses. Seven important DEGs were identified, three were highly expressed and four were lowly expressed. Among them, GPRIN1, MYBL2, and GSTM5 were closely related to prognosis ( This study revealed the important DEGs affecting HCC progression and provided references for clinical assessment of patient prognosis and exploration of HCC progression mechanisms through the construction of predictive models and gene enrichment analysis.
Identifiants
pubmed: 36685007
doi: 10.1155/2023/6707698
pmc: PMC9851787
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6707698Informations de copyright
Copyright © 2023 Yikai Wang et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
Références
Cell Commun Signal. 2022 Apr 7;20(1):49
pubmed: 35392964
Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2838-2846
pubmed: 31002134
Cancers (Basel). 2021 Nov 17;13(22):
pubmed: 34830907
Gastroenterology. 2013 Jul;145(1):176-187
pubmed: 23567350
J Thorac Oncol. 2011 Sep;6(9):1488-95
pubmed: 21792076
Nucleic Acids Res. 2021 Jan 8;49(D1):D325-D334
pubmed: 33290552
Biosci Rep. 2018 Nov 9;38(6):
pubmed: 30341252
Am J Cancer Res. 2021 Feb 01;11(2):389-415
pubmed: 33575078
Eur J Pharmacol. 2019 Sep 15;859:172465
pubmed: 31211984
Front Genet. 2021 Jun 04;12:664393
pubmed: 34149805
Exp Ther Med. 2019 Oct;18(4):2547-2553
pubmed: 31572506
Cell Biol Int. 2019 Apr;43(4):384-393
pubmed: 30599080
Lancet Oncol. 2019 Feb;20(2):282-296
pubmed: 30665869
Oncol Rep. 2020 Jan;43(1):133-146
pubmed: 31746405
World J Gastroenterol. 2014 May 28;20(20):6236-43
pubmed: 24876744
Int J Mol Sci. 2021 May 28;22(11):
pubmed: 34071550
Vaccines (Basel). 2021 May 20;9(5):
pubmed: 34065489
J Oncol. 2021 Aug 26;2021:8533464
pubmed: 34484338
Hepatol Int. 2019 Mar;13(2):125-137
pubmed: 30600478
Oncol Res. 2018 Jul 5;26(6):913-922
pubmed: 29268817
Cancers (Basel). 2021 Jul 08;13(14):
pubmed: 34298648
Int J Mol Sci. 2015 Apr 24;16(5):9236-82
pubmed: 25918934
Mol Cancer. 2017 Aug 30;16(1):149
pubmed: 28854942
N Engl J Med. 2018 Jul 05;379(1):54-63
pubmed: 29972759
Crit Rev Oncol Hematol. 2021 Jan;157:103167
pubmed: 33271389
Liver Int. 2007 Mar;27(2):174-85
pubmed: 17311611
Mol Clin Oncol. 2018 Dec;9(6):597-606
pubmed: 30546887
Cancer Res. 2009 Sep 15;69(18):7385-92
pubmed: 19723656
Cell Transplant. 2019 Dec;28(1_suppl):76S-86S
pubmed: 31822116
Lancet. 2018 Mar 24;391(10126):1163-1173
pubmed: 29433850
Cell Death Dis. 2021 Jan 27;12(1):130
pubmed: 33504766
Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361
pubmed: 27899662
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W214-20
pubmed: 20576703
Open Med (Wars). 2021 Nov 09;16(1):1683-1695
pubmed: 34805531
J Hepatol. 2017 Dec;67(6):1222-1231
pubmed: 28843658
Annu Rev Genet. 2021 Nov 23;55:309-329
pubmed: 34496610
Adv Exp Med Biol. 2014;816:401-35
pubmed: 24818732
N Engl J Med. 2020 May 14;382(20):1894-1905
pubmed: 32402160
Lancet. 2017 Jan 7;389(10064):56-66
pubmed: 27932229
Lancet. 2015 Mar 14;385(9972):977-1010
pubmed: 25467588
Clin Cancer Res. 2021 Feb 15;27(4):1150-1161
pubmed: 33288659
World J Gastroenterol. 2012 Aug 21;18(31):4071-81
pubmed: 22919237
Front Oncol. 2014 Apr 02;4:70
pubmed: 24765614
J Hepatol. 2021 Apr;74(4):893-906
pubmed: 33197513
N Engl J Med. 2008 May 8;358(19):2039-49
pubmed: 18463380
Methods Enzymol. 2004;390:475-83
pubmed: 15488195
Oxid Med Cell Longev. 2018 May 27;2018:3478305
pubmed: 29977454
Adv Cancer Res. 2021;149:1-61
pubmed: 33579421
Liver Cancer. 2021 Jun;10(3):249-259
pubmed: 34239811
Clin Cancer Res. 2015 Apr 15;21(8):1786-8
pubmed: 25628398
Eur Rev Med Pharmacol Sci. 2019 Oct;23(19):8257-8264
pubmed: 31646556