Unravelling the instability of mutational signatures extraction
COSMIC
archetypal analysis
cancer genomics
matrix factorization
mutational signatures
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
09
2022
accepted:
07
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts. The newest version (v3.3) of the signature database available in the Catalogue Of Somatic Mutations In
Identifiants
pubmed: 36685831
doi: 10.3389/fgene.2022.1049501
pii: 1049501
pmc: PMC9846778
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1049501Informations de copyright
Copyright © 2023 Pancotti, Rollo, Birolo, Benevenuta, Fariselli and Sanavia.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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